Product Info Summary
SKU: | MA1040 |
---|---|
Size: | 100 μg/vial |
Reactive Species: | Human |
Host: | Mouse |
Application: | IHC |
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Product info
Product Name
Anti-VEGFR2/KDR Monoclonal Antibody
View all VEGFR2/KDR/Flk-1 Antibodies
SKU/Catalog Number
MA1040
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-VEGFR2/KDR Monoclonal Antibody catalog # MA1040. Tested in IHC applications. This antibody reacts with Human.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-VEGFR2/KDR Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1040)
Host
Mouse
Contents
Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Clonality
Monoclonal
Clone Number
KDR-1
Isotype
Mouse IgG1
Immunogen
Recombinant human extracellular domain of VEGFR-2 (KDR).
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
MA1040 is reactive to KDR in Human
Applications
MA1040 is guaranteed for IHC Boster Guarantee
Observed Molecular Weight
426 kDa
Calculated molecular weight
151.527kDa
Background of VEGFR2/KDR/Flk-1
VEGF, a homodimeric glycoprotein of relative molecular mass 45,000, is the only mitogen that specifically acts on endothelial cells. The importance of VEGF and its receptor system in tumor growth and intervention in this system may provide promising approaches to cancer therapy. VEGF receptor 2 is a member of a receptor tyrosine kinase family. Like other growth factor receptors, upon ligand binding VEGF receptor 2 dimerises and is autophosphorylated on multiple tyrosine residues.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Innovating Scientists Reward
If you are the first to review this product, or if you have results for a special sample, species or application this product is not validated in, share your results with us and receive product credits you can use towards any Boster products! Applicable to all scientists worldwide.
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Assay dilution & Images
Reconsitution
Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry (Frozen Section), 1-2μg/ml, Human
Validation Images & Assay Conditions
Click image to see more details
Boster Kit Box
Protein Target Info & Infographic
Gene/Protein Information For KDR (Source: Uniprot.org, NCBI)
Gene Name
KDR
Full Name
Vascular endothelial growth factor receptor 2
Weight
151.527kDa
Superfamily
protein kinase superfamily
Alternative Names
CD309 antigen; CD309; EC 2.7.10; EC 2.7.10.1; Fetal liver kinase 1; fetal liver kinase-1; Flk1; Flk-1; FLK1tyrosine kinase growth factor receptor; KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); Kinase insert domain receptor; KRD1; Ly73; Protein-tyrosine kinase receptor flk-1; soluble VEGFR2; vascular endothelial growth factor receptor 2; VEGF R2; VEGFR; VEGFR2; VEGFR-2 KDR CD309, FLK1, VEGFR, VEGFR2 kinase insert domain receptor vascular endothelial growth factor receptor 2|fetal liver kinase-1|kinase insert domain receptor (a type III receptor tyrosine kinase)|protein-tyrosine kinase receptor Flk-1|soluble VEGFR2|tyrosine kinase growth factor receptor
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on KDR, check out the KDR Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for KDR: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-VEGFR2/KDR Monoclonal Antibody (MA1040)
Hello CJ!
MA1040 has been cited in 8 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Zhang L,Zhang J,Gong Y,Lv L.Systematic and experimental investigations of the anti-colorectal cancer mediated by genistein. Biofactors.2020 Nov;46(6):974-982.doi:10.1002/biof.1677.Epub 2020 Sep 20.PMID:32951326.
Species: Human,Mouse
MA1040 usage in article: APP:IF, SAMPLE:CRC TISSUE, DILUTION:1:100
Zhou D, Zhan S, Zhou D, Li Z, Lin X, Tang K, Shu H, Chen G, Zeng S, Cai Y, Jiang X. Cell Mol Neurobiol. 2011 Jul;31(5):687-94. Doi: 10.1007/S10571-011-9665-6. Epub 2011 Mar 9. A Study Of The Distribution And Density Of The Vegfr-2 Receptor On Glio...
Li Ql, Huang N, Chen C, Chen Jl, Xiong Kq, Chen Jy, You Tx, Jin J, Liang X. J Biomed Mater Res A. 2010 Sep 15;94(4):1283-93. Doi: 10.1002/Jbm.A.32812. Oriented Immobilization Of Anti-Cd34 Antibody On Titanium Surface For Self-Endothelialization In...
Sun Y, Chen S, Song G, Ren L, Wei L, Liu N, Zhang D, Lv X. Int J Mol Med. 2012 Sep;30(3):622-8. Doi: 10.3892/Ijmm.2012.1032. Epub 2012 Jun 14. Effect Of Visfatin On The Function Of Endothelial Progenitor Cells In High-Fat-Fed Obese Rat...
Lin J, Li G, Den X, Xu C, Liu S, Gao Y, Liu H, Zhang J, Li X, Liang S. Brain Res Bull. 2010 Oct 30;83(5):284-91. Doi: 10.1016/J.Brainresbull.2010.08.002. Epub 2010 Aug 10. Vegf And Its Receptor-2 Involved In Neuropathic Pain Transmission Mediated ...
Liu M, Yang S, Zhang D, Shui P, Song S, Yao J, Dai Y, Sun Q. Int J Clin Exp Med. 2014 Nov 15;7(11):3859-69. Ecollection 2014. Fructopyrano-(1
Ding G, Chen X, Zhu J, Feng Z. Cytotechnology. 2014 May;66(3):395-411. Doi: 10.1007/S10616-013-9587-X. Epub 2013 Jul 24. A Murine-Human Chimeric Igg Antibody Against Vascular Endothelial Growth Factor Receptor 2 Inhibits Angiogenesis In Vitro.
Wang L, Liu X, Wang H, Wang S. Oncol Lett. 2013 Jul;6(1):175-180. Epub 2013 May 15. Correlation Of The Expression Of Vascular Endothelial Growth Factor And Its Receptors With Microvessel Density In Ovarian Cancer.
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Customer Reviews
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Customer Q&As
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5 Customer Q&As for Anti-VEGFR2/KDR Monoclonal Antibody
Question
Our lab were content with the WB result of your anti-VEGFR2/KDR Monoclonal antibody. However we have observed positive staining in umbilical vein cell junction. endoplasmic using this antibody. Is that expected? Could you tell me where is KDR supposed to be expressed?
Verified Customer
Verified customer
Asked: 2020-02-24
Answer
According to literature, umbilical vein does express KDR. Generally KDR expresses in cell junction. endoplasmic, isoform 1: cell membrane. Regarding which tissues have KDR expression, here are a few articles citing expression in various tissues:
Umbilical vein, Pubmed ID: 15815621, 1656371, 7559454
Boster Scientific Support
Answered: 2020-02-24
Question
We are currently using anti-VEGFR2/KDR Monoclonal antibody MA1040 for human tissue, and we are well pleased with the IHC results. The species of reactivity given in the datasheet says human. Is it possible that the antibody can work on horse tissues as well?
Verified Customer
Verified customer
Asked: 2020-01-09
Answer
The anti-VEGFR2/KDR Monoclonal antibody (MA1040) has not been tested for cross reactivity specifically with horse tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in horse you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2020-01-09
Question
What is the recommended dilution protocol of MA1040?
Verified customer
Asked: 2019-10-21
Answer
The recommended dilution of the Anti-VEGFR2/KDR Monoclonal Antibody (MA1040): Concentration: Add 1ml of PBS buffer will yield a concentration of 100ug/ml. Immunohistochemistry(Frozen Section), 1-2μg/ml, Human
Boster Scientific Support
Answered: 2019-10-21
Question
Were you able to test your VEGFR2 antibody against a rabbit VEGFR2 protein?
Verified customer
Asked: 2019-10-17
Answer
We have not tested our Anti-VEGFR2/KDR Monoclonal Antibody MA1040 antibody against a rabbit VEGFR2 protein, so we cannot guarantee that this would work.
Boster Scientific Support
Answered: 2019-10-17
Question
We have seen staining in human lung. Do you have any suggestions? Is anti-VEGFR2/KDR Monoclonal antibody supposed to stain lung positively?
J. Johnson
Verified customer
Asked: 2015-07-13
Answer
According to literature lung does express KDR. According to Uniprot.org, KDR is expressed in lung, umbilical vein, among other tissues. Regarding which tissues have KDR expression, here are a few articles citing expression in various tissues:
Umbilical vein, Pubmed ID: 15815621, 1656371, 7559454
Boster Scientific Support
Answered: 2015-07-13