Anti-SARM SARM1 Antibody

Product Name

Anti-SARM SARM1 Antibody

View all SARM1 Antibodies

SKU/Catalog Number

A03633-1

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-SARM SARM1 Antibody (Catalog # A03633-1). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

SARM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-SARM SARM1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03633-1)

Host

Rabbit

Contents

SARM Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

SARM antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SARM. The immunogen is located within amino acids 30 - 80 of SARM.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. SARM antibody recognize the longest isoform.

Reactive Species

A03633-1 is reactive to SARM1 in Human, Mouse, Rat

Applications

A03633-1 is guaranteed for ELISA, IF, WB Boster Guarantee

Observed Molecular Weight

68 kDa

Calculated molecular weight

79388 MW

Background of SARM1

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-κB, and ultimately the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interleukin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

SARM antibody can be used for detection of SARM by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

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Western blot analysis of SARM in Daudi cell lysate with SARM antibody at (A) 1 and (B) 2 μg/mL.

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Immunofluorescence of SARM in human kidney tissue with SARM antibody at 20 μg/mL.

Gene/Protein Information For SARM1 (Source: Uniprot.org, NCBI)

Alternative Names

KIAA0524SAM domain-containing protein 2; SAMD2; SAMD2sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; SARM1; SARMFLJ36296; Sterile alpha and Armadillo repeat protein; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; Tir-1 homolog SARM1 HsTIR, MyD88-5, SAMD2, SARM, hSARM1 sterile alpha and TIR motif containing 1 NAD(+) hydrolase SARM1|NADP(+) hydrolase SARM1|NADase SARM1|SAM domain-containing protein 2|sterile alpha and Armadillo repeat protein|sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila|sterile alpha and TIR motif-containing protein 1|sterile alpha motif domain-containing protein 2|tir-1 homolog

For more info on SARM1, check out the SARM1 Infographic

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In this infographic, you will see the following information for SARM1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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