NAD(+) hydrolase SARM1 Antibodies

AND SARM1 ELISA kits, NAD(+) hydrolase SARM1 Proteins

Many biological assays use antibodies to detect NAD(+) hydrolase SARM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NAD(+) hydrolase SARM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NAD(+) hydrolase SARM1 antibodies...

We validate the specificity of these antibodies to NAD(+) hydrolase SARM1 by testing them on tissues known to express SARM1 positively and negatively. Browse below to find the SARM1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SARM1 Infographic by Boster Bio

All SARM1 Products

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Anti-SARM SARM1 Antibody

Human, Mouse

ELISA, IF, ICC, WB

$449
Cat # A03633
0.1 mg

Anti-SARM SARM1 Antibody

Human, Mouse, Rat

ELISA, IF, WB

$449
Cat # A03633-1
0.1 mg

SARM1 Overview

Facts about NAD(+) hydrolase SARM1.

SARM1 3D structure. Source: alphafold

NAD(+) hydrolase SARM1 (SARM1)

Negative regulator of MYD88- and TRIF-dependent toll- like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site.

Can trigger neuronal death in response to anxiety. Regulates dendritic arborization through the MAPK4-JNK pathway.

Gene Information

Human
Gene Name:	SARM1
Uniprot:	Q6SZW1
Entrez:	23098

Family

Belongs to:

SARM1 family

Alternative Names

KIAA0524SAM domain-containing protein 2; SAMD2; SAMD2sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; SARM1; SARMFLJ36296; Sterile alpha and Armadillo repeat protein; sterile alpha and TIR motif containing 1; sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; Tir-1 homolog

Molecular Weight

Mass (kDA):
79.388 kDA

Genomic Context


Human

Location:	17q11.2
Sequence:	17; NC_000017.11 (28371694..28404049)

Tissue Specificity

Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta.

Subcellular Localizations

Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Mitochondrion. Associated with microtubules.

Diseases

Communicable Diseases
Malignant Neoplasms
Bacterial Infections
Inflammation
Neurodegenerative Disorders
Age Related Macular Degeneration
Innate Immune Response
Wallerian Degeneration
Mycoses
Colorectal Cancer
Porcine Reproductive And Respiratory Syndrome
Brain Injuries
Infective Disorder

Liver Carcinoma
Malignant Paraganglionic Neoplasm
Tissue Adhesions
Retinoschisis
Autoimmune Diseases
Virus Diseases
Adenomatous Polyposis Coli

Interacting Proteins

MYD88
TICAM2

Pathways

Immune Response
Localization
Cell Adhesion
Blood Coagulation
Cytokine Secretion
Signalosome Assembly
Coagulation
Calcium-mediated Signaling
Cell Death
Cellular Localization

Protein Folding
Innate Immune Response
Pathogenesis
Rna Interference
Secretion

PTMs

Phosphorylation
Cleavage

Acetylation
Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SARM1

References

PMID: 11386760 by Mink M., et al. A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans.

PMID: 15123841 by Liberati N.T., et al. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.