Product Info Summary
SKU: | A03633 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-SARM SARM1 Antibody
SKU/Catalog Number
A03633
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-SARM SARM1 Antibody (Catalog # A03633). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
SARM antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-SARM SARM1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03633)
Host
Rabbit
Contents
SARM Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SARM antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human SARM. The immunogen is located within amino acids 640 - 690 of SARM.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
AKT1S1 antibody is human, mouse and rat reactive. At least three isoforms of AKT1S1 are known to exist.
Reactive Species
A03633 is reactive to SARM1 in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
79388 MW
Background of SARM1
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-κB, and ultimately the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interluekin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03633 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SARM antibody can be used for detection of SARM by Western blot at 0.5 to 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2 μg/mL. For immunofluorescence start at 2 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SARM in Daudi cell lysate with SARM antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunocytochemistry staining of Daudi cells using SARM antibody at 2 μg/mL.
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Immunofluorescence of SARM in Daudi cells with SARM antibody at 2 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SARM1 (Source: Uniprot.org, NCBI)
Gene Name
SARM1
Full Name
NAD(+) hydrolase SARM1
Weight
79388 MW
Superfamily
SARM1 family
Alternative Names
SARM, SAMD2, MyD88-5, KIAA0524, SARM, Sterile alpha and TIR motif-containing protein 1, Sterile alpha and Armadillo repeat protein SARM1 HsTIR, MyD88-5, SAMD2, SARM, hSARM1 sterile alpha and TIR motif containing 1 NAD(+) hydrolase SARM1|NADP(+) hydrolase SARM1|NADase SARM1|SAM domain-containing protein 2|sterile alpha and Armadillo repeat protein|sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila|sterile alpha and TIR motif-containing protein 1|sterile alpha motif domain-containing protein 2|tir-1 homolog
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SARM1, check out the SARM1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SARM1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-SARM SARM1 Antibody (A03633)
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