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Key=sku, value=A00455-1
Key=has_options, value=1
Key=required_options, value=1
Key=created_at, value=2020-05-29 05:53:19
Key=updated_at, value=2024-09-26 01:15:46
Key=mst_search_weight, value=0
Key=status, value=Enabled
Key=name, value=Anti-CXCR2 Antibody
Key=cj_search_index
Key=publication_count, value=3
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Key=is_recurring, value=Yes
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Key=featured, value=No
Key=featured_image, value=Yes
Key=fb_product, value=
Key=custom_product_page, value=No
Key=free_shipping, value=No
Key=template, value=antibodies
Key=host, value=Rabbit
Key=quantity_and_stock_status
Key=googleshopping_exclude, value=No
Key=yoast_keyword_score, value=-1195
Key=yoast_content_score, value=30
Key=badge, value=free-antibody-validation
Key=price, value=370.0000
Key=weight, value=1.0000
Key=meta_title, value=Anti-CXCR2 Antibody Picoband®| Bosterbio
Key=meta_description, value=Boster Bio Anti-CXCR2 Antibody catalog # A00455-1. Tested in Flow Cytometry, IHC applications. This antibody reacts with Human.
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Key=url_key, value=anti-cxcr2-picoband-trade-antibody-a00455-1-boster
Key=url_path, value=anti-lipocalin-2-ngal-picoband-trade-antibody-a00452-boster
Key=options_container, value=Product Info Column
Key=msrp_display_actual_price_type, value=Use config
Key=gift_message_available, value=No
Key=size, value=100 μg/vial
Key=protein_name, value=Neutrophil gelatinase-associated lipocalin
Key=gene_full_name, value=Neutrophil gelatinase-associated lipocalin
Key=uniprot_id, value=P25025
Key=reconstitution, value=Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Key=applications, value=Flow Cytometry, IHC
Key=reactivity, value=Human
Key=form, value=Lyophilized
Key=concentration, value=Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Key=cross_reactivity, value=No cross-reactivity with other proteins
Key=recommended_detection_systems, value=Boster recommends HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P).
Key=predicted_reactivity
Key=source_company, value=Boster A00455-1
Key=isotype, value=Rabbit IgG
Key=molecular_weight, value=22875 MW
Key=sample_size_available, value=30ug for $99, contact us for details
Key=related_product_skus, value=B0001-5,AR1156,AR0146
Key=product_category, value=Primary Antibodies
Key=research_category, value=Immunoglobulins, Immunology
Key=clonality, value=Polyclonal
Key=swatch_image, value=no_selection
Key=rating_value, value=100
Key=review_count, value=5
Key=mp_exclude_sitemap, value=Yes
Key=yoast_facebook_image, value=/a/0/a00454-2-pak1-primary-antibodies-wb-testing-1.jpg
Key=yoast_twitter_image, value=/a/0/a00454-2-pak1-primary-antibodies-wb-testing-1.jpg
Key=cj_related_products, value=Neutrophil Activation:EK0728|PROTP14095-1^Receptor Internalization:A00737S375|A01677-1|A01677-Dyl488|A01677-Dyl550
Key=description, value=Boster Bio Anti-CXCR2 Antibody catalog # A00455-1. Tested in Flow Cytometry, IHC applications. This antibody reacts with Human.
Key=short_description, value=Boster Bio Anti-CXCR2 Antibody catalog # A00455-1. Tested in Flow Cytometry, IHC applications. This antibody reacts with Human.
Key=meta_keyword, value=Anti-CXCR2 Antibody Picoband®
Key=contents, value=Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
Key=background, value=CXCR2 is a receptor for Interleukin 8, which is a powerful neutrophil chemotactic factor. It is a member of the GPCR family (subfamily, chemokine). Binding of IL8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL8 with a high affinity and to GRO/MGSA and NAP2 also with a high affinity. It has been reported to be expressed in a wide variety of tissues. ESTs have been isolated from human placenta and thymus libraries.
Key=gene_name, value=CXCR2
Key=synonyms, value=Neutrophil gelatinase-associated lipocalin;NGAL;Lipocalin-2;SV-40-induced 24P3 protein;Siderocalin LCN2;p25;Lcn2;
Key=application_details, value=Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human

Key=subcellular_localization, value= Secreted . Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.
Key=tissue_specificity, value= Detected in lung, spleen, uterus, vagina and epididymis. .
Key=protein_function, value= Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. .
Key=application_notes, value=Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
Key=competitor_equivalent_skus, value=sc 18695|sc 50350|sc 57517|sc 57518|sc 59622
Key=immunogen, value=A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR2, which shares 52.4% amino acid (aa) sequence identity with rat CXCR2.
Key=purification, value=Immunogen affinity purified.
Key=storage, value=Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Key=custom_attribute_1, value=68 kDa
Key=custom_attribute_2, value=IHC: human spleen tissue
FCM: human PBMC cell
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