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CXCR2 Antibodies
AND CXCR2 ELISA kits, CXCR2 Proteins
Many biological assays use antibodies to detect CXCR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CXCR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CXCR2 antibodies...
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CXCR2 Infographic by Boster Bio
All CXCR2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, IF, IHC-P, ICC, WB
$380
Cat # A00455S347
100ul
Cat # A00455S347
100ul
Anti-CXCR2 Antibody Picoband®
3 Citations
Human
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00455-2
100 μg/vial
Cat # A00455-2
100 μg/vial
Anti-CXCR2 Antibody Picoband®
4 Citations
Human
ELISA, Flow Cytometry, WB
$370
Cat # A00455-3
100 μg/vial
Cat # A00455-3
100 μg/vial
CXCR2 Overview
Facts about C-X-C chemokine receptor type 2.
C-X-C chemokine receptor type 2 (CXCR2)
Receptor for interleukin-8 that's a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils.
This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity.
Gene Information
| Human | |
|---|---|
| Gene Name: | CXCR2 |
| Uniprot: | P25025 |
| Entrez: | 3579 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
CD182 antigen; CD182; CDw128b; chemokine (C-X-C motif) receptor 2; chemokine (CXC) receptor 2; CMKAR2; C-X-C chemokine receptor type 2; CXCR2 gene for IL8 receptor type B; CXCR2; CXC-R2; CXCR-2; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8 RB; IL-8 receptor type 2; IL-8R B; IL8R2; IL8RA; IL8RB; interleukin 8 receptor B; interleukin 8 receptor type 2; interleukin-8 receptor type B
Molecular Weight
Mass (kDA):
40.759 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q35 |
| Sequence: | 2; NC_000002.12 (218125294..218137253) |
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Inflammation
- Neoplasms
- Malignant Neoplasms
- Tumor Angiogenesis
- Tissue Adhesions
- Pathologic Neovascularization
- Neoplasm Metastasis
- Inflammatory Response
- Cholangiocarcinoma
- Lung Diseases
- Chronic Obstructive Airway Disease
- Pneumonia
Interacting Proteins
- CXCL8
- IQGAP1
Pathways
- Chemotaxis
- Angiogenesis
- Pathogenesis
- Secretion
- Inflammatory Response
- Cell Migration
- Neutrophil Chemotaxis
- Cell Proliferation
- Immune Response
- Receptor Internalization
- Cell Adhesion
- Neutrophil Activation
- Leukocyte Migration
PTMs
- Phosphorylation
- Cleavage
- Acetylation
- Methylation
- Dephosphorylation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CXCR2
bosterbio.com/bosterbio-gene-info-cards/CXCR2
References
PMID: 1891716 by Murphy P.M., et al. Cloning of complementary DNA encoding a functional human interleukin- 8 receptor.
PMID: 8384312 by Cerretti D.P., et al. Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.
13 Publications of Boster CXCR2 Antibodies & ELISA Kits
- PubMed ID: 10.1177/1744806916646381, Overexpression of GRK6 attenuates neuropathic pain via suppression of CXCR2 in r...
- PubMed ID: 10.1097/j.pain.0000000000000339, Spinal translocator protein alleviates chronic neuropathic pain behavior and mod...
- PubMed ID: 10.1016/j.expneurol.2014.05.014, Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity ...
- PubMed ID: 10.1016/j.brainresbull.2016.09.016, Chemokine receptor CXCR2 in dorsal root ganglion contributes to the maintenance ...
- PubMed ID: , Connexin-43 induces chemokine release from spinal cord astrocytes to maintain la...
- PubMed ID: 30404567, Cui D,Zhao Y,Xu J.Activation of CXCL5-CXCR2 axis promotes proliferation and acce...
- PubMed ID: -, Anqi Xia,Huan Huang,Wenjun You et al.The neuroprotection of hyperbaric oxygen th...
- PubMed ID: 30404567, Activation of CXCL5-CXCR2 axis promotes proliferation and accelerates G1 to S ph...
- PubMed ID: 27145805, Overexpression of GRK6 attenuates neuropathic pain via suppression of CXCR2 in r...
- PubMed ID: 24852102, Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity ...
- PubMed ID: 24580964, Xu J, Zhu Md, Zhang X, Tian H, Zhang Jh, Wu Xb, Gao Yj. J Neuroinflammation. 201...
- PubMed ID: 24919967, Chen G, Park Ck, Xie Rg, Berta T, Nedergaard M, Ji Rr. Brain. 2014 Aug;137(Pt 8)...
- PubMed ID: 23831863, Zhang Zj, Cao Dl, Zhang X, Ji Rr, Gao Yj. Pain. 2013 Oct;154(10):2185-97. Doi: 1...
*More publications can be found for each product on its corresponding product page