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Key=sku, value=EKC2274
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Key=created_at, value=2019-02-12 00:21:01
Key=updated_at, value=2024-09-26 01:01:53
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Key=status, value=Enabled
Key=name, value=Smad2/3 (Phospho-Thr8) Colorimetric Cell-Based ELISA Kit
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Key=template, value=cell-based-phospho-elisa-kits
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Key=price, value=540.0000
Key=weight, value=1.0000
Key=meta_title, value=Smad2/3 (Phospho-Thr8) Colorimetric Cell-Based ELISA Kit Price
Key=meta_description, value=Smad2/3 (Phospho-Thr8) Colorimetric Cell-Based ELISA Kit EKC2274
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Key=url_key, value=smad2-3-phospho-thr8-colorimetric-cell-based-elisa-kit-ekc2274-boster
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Key=size, value=1 kit, containing two 96-well plates and all necessary reagents
Key=gene_full_name, value=Mothers against decapentaplegic homolog 3
Key=uniprot_id, value=P84022
Key=assay_range, value=> 5000 cells/well
Key=applications, value=ELISA
Key=reactivity, value=Human, Mouse, Rat
Key=source_company, value=AssayBiotech CBP1393; Cost: 300
Key=molecular_weight, value=48081 MW
Key=product_category, value=Cell-Based ELISA Kits
Key=rating_value, value=100
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Key=cj_related_products, value=Hepatic Fibrosis:M00059S425|EK0513-BV|EK0520|PA1385|A00561-2|PROTP01033
Key=description, value=The Smad2/3 (Phospho-Thr8) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Smad2/3 (Phospho-Thr8) protein expression profile in cells. The kit can be used for measuring the relative amounts of Smad2/3 (Phospho-Thr8) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Smad2/3 (Phospho-Thr8).
Key=short_description, value=The Smad2/3 (Phospho-Thr8) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Smad2/3 (Phospho-Thr8) protein expression profile in cells. The kit can be used for measuring the relative amounts of Smad2/3 (Phospho-Thr8) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Smad2/3 (Phospho-Thr8).
Key=gene_name, value=SMAD3
Key=synonyms, value=JV15-2;MAD-3;MADH3;Mad3;Mothers against DPP homolog 3;Mothers against decapentaplegic homolog 3;SMAD 3;Smad 3
Key=sample_type, value=Cell lines
Key=kit_components, value=Smad2/3 (Phospho-Thr8)
Key=subcellular_localization, value=Cytoplasm. Nucleus. Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:15799969). Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15601644). MAPK-mediated phosphorylation appears to have no effect on nuclear import (PubMed:19218245). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236).
Key=protein_function, value= Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF- mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Key=storage, value=Store at 4°C for up to 6 months.
Key=custom_attribute_1, value=Smad2/3
Key=custom_attribute_2, value=Phospho-Thr8
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