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SMAD3 Antibodies
AND SMAD3 ELISA kits, SMAD3 Proteins
Many biological assays use antibodies to detect SMAD3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMAD3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMAD3 antibodies...
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SMAD3 Infographic by Boster Bio
All SMAD3 Products
Product
Figures
Specificity
Applications
Price
Anti-Phospho-SMAD3 S423/S425 Antibody
4 Citations 15 Q&As
Human
ELISA, IHC, WB
$629
Cat # P00059
100ug
Cat # P00059
100ug
Anti-Phospho-Smad3 (S423 + S425) Rabbit Monoclonal Antibody
1 Citations 6 Q&As
Human, Mouse
IF, IHC, ICC, WB
$370
Cat # P00059-1
100 μl
Cat # P00059-1
100 μl
Anti-Smad3 Rabbit Monoclonal Antibody
2 Citations 17 Q&As
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00059
100 μl
Cat # M00059
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1528
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1528
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1529
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1529
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1960
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1960
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2274
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2274
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2275
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2275
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2276
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2276
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2277
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2277
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2278
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2278
1 kit, containing two 96-well plates and all necessary reagents
Anti-Smad2/3 (phospho-T8) SMAD3 Antibody
1 Citations
Human, Mouse, Rat
IP, IF, WB
$482
Cat # A00059T8
100ul
Cat # A00059T8
100ul
SMAD3 Overview
Facts about Mothers against decapentaplegic homolog 3.
Mothers against decapentaplegic homolog 3 (SMAD3)
Receptor-regulated SMAD (R-SMAD) which is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of several genes which are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription.
Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by changing the TGF- mediated chemotaxis of monocytes.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMAD3 |
| Uniprot: | P84022 |
| Entrez: | 4088 |
Family
| Belongs to: |
|---|
| dwarfin/SMAD family |
Alternative Names
DKFZp586N0721; DKFZp686J10186; hMAD-3; hSMAD3; HsT17436; JV15-2MGC60396; MAD homolog 3; mad protein homolog; MAD, mothers against decapentaplegic homolog 3 (Drosophila); MAD, mothers against decapentaplegic homolog 3; mad3; MADH3mad homolog JV15-2; mothers against decapentaplegic homolog 3; Mothers against DPP homolog 3; SMA- and MAD-related protein 3; SMAD 3; SMAD family member 3HSPC193; SMAD, mothers against DPP homolog 3 (Drosophila); SMAD, mothers against DPP homolog 3; Smad3
Molecular Weight
Mass (kDA):
48.081 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q22.33 |
| Sequence: | 15; NC_000015.10 (67065602..67195195) |
Subcellular Localizations
Cytoplasm. Nucleus. Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:15799969). Through the action of the phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15601644). MAPK-mediated phosphorylation appears to have no effect on nuclear import (PubMed:19218245). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236).
Diseases
- Fibrosis
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Carcinoma
- Cell Transformation, Neoplastic
- Kidney Diseases
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Cell Invasion
- Carcinogenesis
- Hepatic Fibrosis
- Pulmonary Fibrosis
Interacting Proteins
- AES
- BLZF1
- CHRD
- CPSF7
- CRX
- DAB2
- DDX5
- DOCK9
- EPAS1
- FOXH1
Pathways
- Cell Proliferation
- Pathogenesis
- Cell Growth
- Cell Cycle
- Localization
- Secretion
- Wound Healing
- Cell Differentiation
- Angiogenesis
- Cell Cycle Arrest
- Cell Migration
- Rna Interference
- Cell Death
PTMs
- Phosphorylation
- Ubiquitination
- Acetylation
- Dephosphorylation
- Cleavage
- Methylation
- Reduction
- Sumoylation
- Deacetylation
- Demethylation
Research Areas
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMAD3
bosterbio.com/bosterbio-gene-info-cards/SMAD3
References
PMID: 8774881 by Zhang Y., et al. Receptor-associated Mad homologues synergize as effectors of the TGF- beta response.
PMID: 8673135 by Riggins G.J., et al. Mad-related genes in the human.
8 Publications of Boster SMAD3 Antibodies & ELISA Kits
- PubMed ID: 34093874, Wang Q,Liu J,Hu Y,Pan T,Xu Y,Yu J,Xiong W,Zhou Q,Wang Y.Local administration of ...
- PubMed ID: -, Hang Liang,Qian Wang,Ding Wang,Hongwu Zheng,Dhan V. Kalvakolanu,Hua Lu,Naiyan We...
- PubMed ID: -, Huanyue Cui,Xueying Liu,Jin Zhang,Ke Zhang,Dahong Yao,Shi Dong,Shushu Feng,Lu Ya...
- PubMed ID: 32826874, Hong L,Li F,Tang C,Li L,Sun L,Li X,Zhu L.Semaphorin 7A promotes endothelial to m...
- PubMed ID: 25483171, Molecular responses of radiation-induced liver damage in rats
- PubMed ID: 28871336, Cheng L, Ge M, Lan Z, Ma Z, Chi W, Kuang W, Sun K, Zhao X, Liu Y, Feng Y, Huang ...
- PubMed ID: 25356121, Shi K, Jiang J, Ma T, Xie J, Duan L, Chen R, Song P, Yu Z, Liu C, Zhu Q, Zheng J...
- PubMed ID: 25820389, Xu T, Ni Mm, Huang C, Meng Xm, He Yh, Zhang L, Li J. Inflammation. 2015 Oct;38(5...
*More publications can be found for each product on its corresponding product page