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Product Info Summary
| SKU: | A01409 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-TXNIP Antibody
SKU/Catalog Number
A01409
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TXNIP Antibody (Catalog # A01409). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TXNIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-TXNIP Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01409)
Host
Rabbit
Contents
TXNIP antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TXNIP antibody was raised against a 16 amino acid peptide near the center of human TXNIP. The immunogen is located within amino acids 110 - 160 of TXNIP.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
TXNIP antibody is human, mouse and rat reactive.
Reactive Species
A01409 is reactive to TXNIP in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
43661 MW
Background of TXNIP
Thioredoxin-interacting protein (TXNIP) belongs to the arrestin family and plays a critical role in the antioxidant defense mechanisms of hematopoietic cells by activating the p53 pathway during oxidative stress (1,2). It functions as a transcriptional repressor and acts as an oxidative stress mediator by inhibiting thioredoxin activity (2). TXNIP expression is reduced in many types of tumors, and TXNIP overexpression inhibits tumor growth by blocking cell-cycle progression (3). It has recently reported that TXNIP deficiency correlates with a high incidence of hepatocellular carcinoma (HCC) (4). TXNIP and p53 interactions could potentially be a therapeutic target for oxidative stress-related diseases such as hematopoietic malignancies and metabolic diseases (5).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01409 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TXNIP body can be used for detection of TXNIP by Western blot at 0.5 - 1 μg/ml. Antibody can also be used for Immunohistochemistry at 2 μg/mL. For Immunoflorescence start at 5 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TXNIP in C2C12 cell lysate with TXNIP antibody at 0.5 μg/ml in (A) the absence and (B) the presence of blocking peptide.
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Immunohistochemistry of TXNIP in human kidney tissue with TXNIP antibody at 2 μg/ml.
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Immunofluorescence of TXNIP in human kidney tissue with TXNIP antibody at 5 μg/ml.
Red: TXNIP Antibody (A01409)
Blue: DAPI staining
Protein Target Info & Infographic
Gene/Protein Information For TXNIP (Source: Uniprot.org, NCBI)
Gene Name
TXNIP
Full Name
Thioredoxin-interacting protein
Weight
43661 MW
Superfamily
arrestin family
Alternative Names
Thioredoxin-interacting protein, BMP and activin membrane-bound inhibitor homolog, non-metastatic gene A protein, NMA TXNIP ARRDC6, EST01027, HHCPA78, THIF, VDUP1 thioredoxin interacting protein thioredoxin-interacting protein|thioredoxin binding protein 2|upregulated by 1,25-dihydroxyvitamin D-3|vitamin D3 up-regulated protein 1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TXNIP, check out the TXNIP Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TXNIP: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TXNIP Antibody (A01409)
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