TXNIP Antibodies

Thioredoxin-interacting protein (TXNIP)

May act as an oxidative stress mediator by inhibiting thioredoxin action or by restricting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm.

Functions as a transcriptional repressor, perhaps by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.

Gene Information

Human
Gene Name:	TXNIP
Uniprot:	Q9H3M7
Entrez:	10628

Family

Belongs to:
arrestin family

Alternative Names

HHCPA78; THIF; thioredoxin binding protein 2; thioredoxin interacting protein; Thioredoxin-binding protein 2; thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; VDUP1EST01027; Vitamin D3 up-regulated protein 1

Molecular Weight

Mass (kDA):
43.661 kDA

Genomic Context

Human
Location:	1q21.1
Sequence:	1; NC_000001.11 (145992435..145996579, complement)

Subcellular Localizations

Cytoplasm.

Diseases

• Malignant Neoplasms
• Diabetes Mellitus
• Neoplasms
• Inflammation
• Hyperglycemia
• Diabetes Mellitus, Non-insulin-dependent
• Diabetes Mellitus, Experimental
• Hyperlipidemia
• Carcinoma
• Hypoxia
• Malignant Neoplasm Of Breast
• Carcinogenesis
• Leukemia

• Kidney Diseases
• Diabetic Nephropathy
• Tumor Angiogenesis
• Cardiovascular Diseases
• Insulin Resistance
• Atherosclerosis
• Neoplasm Metastasis

Interacting Proteins

• ECD
• TXN
• VAV2

Pathways

• Pathogenesis
• Secretion
• Cell Growth
• Cell Proliferation
• Cell Death
• Cell Cycle
• Localization
• Insulin Secretion
• Glucose Homeostasis
• Angiogenesis
• Aging
• Rna Interference
• Glycolysis

• Translation
• Senescence
• Energy Homeostasis
• Gene Silencing
• Reverse Transcription
• Cell Adhesion
• Response To Oxidative Stress

PTMs

• Reduction
• Phosphorylation
• Cleavage
• Oxidation
• Acetylation
• Nitrosylation

• Methylation
• Ubiquitination
• Deacetylation
• Glutathionylation
• Nitration
• Glycosylation

• Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TXNIP

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