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Product Info Summary
| SKU: | M02039 |
|---|---|
| Size: | 100μg/vial |
| Reactive Species: | Mouse |
| Host: | Mouse |
| Application: | IP, ICC |
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Product info
Product Name
Anti-Tollip Antibody (Monoclonal, Kimmy-2)
SKU/Catalog Number
M02039
Size
100μg/vial
Form
Liquid
Description
Boster Bio Anti-Tollip Antibody (Monoclonal, Kimmy-2) catalog # M02039. Tested in IP, ICC applications. This antibody reacts with Mouse.
Storage & Handling
Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Tollip Antibody (Monoclonal, Kimmy-2) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M02039)
Host
Mouse
Contents
Each vial contains 0.02% sodium azide.
Clonality
Monoclonal
Clone Number
Kimmy-2
Isotype
IgG1 Kappa
Immunogen
Recombinant mouse Tollip (aa 1-274).
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
M02039 is reactive to Tollip in Mouse
Reconstitution
Observed Molecular Weight
42 kDa
Calculated molecular weight
30345 MW
Background of TOLLIP
TOLLIP (TOLL-Interacting Protein), is an inhibitory adaptor protein that in humans is encoded by the TOLLIP gene. Lo et al. (2009) stated that the TOLLIP gene maps to chromosome 11. The mouse gene maps to chromosome 7. By Western blot analysis of embryonic kidney cells, Burns et al. (2000) confirmed the binding of TOLLIP to IL1RAP, to a complex of IL1RAP-IL1R1, and to IL18R. Burns et al. (2000) proposed that IL1B stimulation induces aggregation of IL1Rs, recruitment of MYD88 followed by TOLLIP-IRAK complexes, and the phosphorylation of IRAK by MYD88. This leads to the dissociation of TOLLIP from IRAK, which can then transmit the IL1-induced signals.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M02039 is guaranteed for IP, ICC Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ICC, 1:100, Mouse
Validation Images & Assay Conditions
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Tollip was detected in Tollip -/-(A) or overexpressed Tollip in -/-(B) murine embryonic fibroblasts (MEF) cells using mouse anti-Tollip monoclonal antibody (Catalog # M02039) at 1:100. The immunocytochemical sections were developed using SABC method (Catalog # SA1092).
Protein Target Info & Infographic
Gene/Protein Information For Tollip (Source: Uniprot.org, NCBI)
Gene Name
Tollip
Full Name
Toll-interacting protein
Weight
30345 MW
Superfamily
tollip family
Alternative Names
Toll-interacting protein;Tollip; TOLLIP IL-1RAcPIP toll interacting protein toll-interacting protein|adapter protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Tollip, check out the Tollip Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Tollip: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Tollip Antibody (Monoclonal, Kimmy-2) (M02039)
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