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Product Info Summary
| SKU: | A03373 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | ELISA, ICC, WB |
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Product info
Product Name
Anti-SIGIRR Antibody
SKU/Catalog Number
A03373
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-SIGIRR Antibody (Catalog # A03373). Tested in ELISA, WB, ICC applications. This antibody reacts with Human, Mouse.
Storage & Handling
SIGIRR antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-SIGIRR Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03373)
Host
Rabbit
Contents
SIGIRR Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SIGIRR antibody was raised against a synthetic peptide corresponding to 15 amino acids at the C-terminus of human SIGIRR. The immunogen is located within the last 50 amino acids of SIGIRR.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of TET3 are known to exist. TET3 antibody is predicted to not cross react with other TET proteins.
Reactive Species
A03373 is reactive to SIGIRR in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
45679 MW
Background of Sigirr
SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03373 is guaranteed for ELISA, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SIGIRR antibody can be used for the detection of SIGIRR by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SIGIRR expression in (A) A549 and (B) MCF7 cell lysate with SIGIRR antibody at 1 μg/ml.
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Immunocytochemistry of SIGIRR in A549 cells with SIGIRR antibody at 10 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SIGIRR (Source: Uniprot.org, NCBI)
Gene Name
SIGIRR
Full Name
Single Ig IL-1-related receptor
Weight
45679 MW
Superfamily
interleukin-1 receptor family
Alternative Names
TIR8, Single Ig IL-1-related receptor, Single Ig IL-1R-related molecule, TIR8 Sigirr|AI256711, S, TIR8, Ti|single immunoglobulin and toll-interleukin 1 receptor (TIR) domain|single Ig IL-1-related receptor|single Ig IL-1 receptor related protein|single Ig IL-1R-related molecule|single Ig IL-1R-related protein|single immunoglobulin domain-containing IL1R-related protein|toll/interleukin-1 receptor 8
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SIGIRR, check out the SIGIRR Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SIGIRR: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-SIGIRR Antibody (A03373)
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