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- Table of Contents
1 Citations 3 Q&As
Facts about Toll-interacting protein.
Component of the signaling pathway of IL-1 and Toll-like receptors.
Inhibits cell activation by microbial products.Recruits IRAK1 into the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856).
Human | |
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Gene Name: | TOLLIP |
Uniprot: | Q9H0E2 |
Entrez: | 54472 |
Belongs to: |
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tollip family |
adapter protein; FLJ33531; IL-1RAcPIP; toll interacting protein; toll-interacting protein; Tollip
Mass (kDA):
30.282 kDA
Human | |
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Location: | 11p15.5 |
Sequence: | 11; NC_000011.10 (1274368..1309632, complement) |
Cytoplasm.
PMID: 10854325 by Burns K., et al. Tollip, a new component of the IL-1R1 pathway, links IRAK to the IL-1 receptor.
PMID: 11751856 by Zhang G., et al. Negative regulation of Toll-like receptor-mediated signaling by Tollip.
*More publications can be found for each product on its corresponding product page