Toll-interacting protein Antibodies

Toll-interacting protein (TOLLIP)

Component of the signaling pathway of IL-1 and Toll-like receptors.

Inhibits cell activation by microbial products.

Recruits IRAK1 into the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856).

Gene Information

Human
Gene Name:	TOLLIP
Uniprot:	Q9H0E2
Entrez:	54472

Family

Belongs to:
tollip family

Alternative Names

adapter protein; FLJ33531; IL-1RAcPIP; toll interacting protein; toll-interacting protein; Tollip

Molecular Weight

Mass (kDA):
30.282 kDA

Genomic Context

Human
Location:	11p15.5
Sequence:	11; NC_000011.10 (1274368..1309632, complement)

Subcellular Localizations

Cytoplasm.

Diseases

• Inflammation
• Innate Immune Response
• Inflammatory Response
• Malignant Neoplasms
• Asthma
• Infective Disorder
• Cell Invasion
• Systemic Infection
• Tuberculosis
• Bacterial Infections
• Autoimmune Diseases
• Colitis
• Autoimmune Reaction

• Autoimmunity
• Ulcer
• Vaccinia
• Fish Diseases
• Atherosclerosis
• Salmonella Infections
• Huntington Disease

Interacting Proteins

• ACTN2
• CSTF1
• DAB1
• DAZAP2
• DZIP3

• EIF2AK2
• IRAK2
• MAP1LC3A
• PEG10
• RBPMS

• RHOXF2
• TOM1
• TOM1L1
• WDYHV1
• WRNIP1

Pathways

• Immune Response
• Inflammatory Response
• Innate Immune Response
• Pathogenesis
• Secretion
• Localization
• Cytokine Secretion
• Reverse Transcription
• Cell Activation
• Adaptive Immune Response
• Toll-like Receptor Signaling Pathway
• Endocytosis
• Cytokine Production

• Transport
• Response To Lipopolysaccharide
• Response To Lipoteichoic Acid
• Hyperphosphorylation
• Aging
• Protein Sumoylation
• Tumor Necrosis Factor Production

PTMs

• Phosphorylation
• Ubiquitination
• Sumoylation

• Cleavage
• Methylation
• Ribosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TOLLIP

Boster Bio - Best Uses Of The TOLLIP Marker

Boster Bio is the best choice when you are looking for a high affinity tolllip marker. Their high-affinity primary antibodies are widely cited over the past 25 years and have been validated for use in Western Blotting, Immunohistochemistry, and ELISA. Research communities can trust them. Boster's TOLLIP markings are however unique.

Boster offers high-affinity prim antibodies

A highly specific antibody against TOLLIP is essential for a successful cancer immunotherapy program. The TOLLIP marker is a peptide derived from a rabbit polyclonal antigen. It can be used to identify and predict the response of tumor cells to anti-tumor treatments. Boster Bio offers primary antibodies to this marker for immunotherapy trials.

Boster offers colorimetric detection technology

A colorimetric detection tool is a sophisticated tool that allows for rapid and precise identification of various improvised explosives. Its design is inspired molecular logic gates that allow for massive parallel information processing. The system uses four test molecules and their constituents to produce rapid colour changes. This test can be used in security applications such as improvised explosives detection. The colorimetric detection system can also be used for medical research and forensics.

C granulomatis colorimetric detector system has two levels of specificity. The colorimetric system can be carried around easily and has automated analysis capabilities. This method can be used in routine clinical laboratories to diagnose donovanosis. Its sensitivity compares to laboratory-based, spectrophotometers. The system also features two-step colorimetric analysis methods that are applicable to diverse geographical areas.

Boster offers ECL chemiluminescent detection systems

The ECL chemiluminescent detection systems used in bioassays can be a great way to screen for specific proteins, or to detect biomarkers that may be incompatible with existing methods. Boster Bio offers two types of ECL systems: the primary-secondary-ABC system and the Supervision chemiluminescent detection system. The primary-secondary-ABC system uses avidins conjugated to signal molecules such as Horseradish Peroxide, HRP. This method offers high sensitivity and specificity, with low background. Other detection systems can also be used, such as those that use organic polymers and polysaccharides. Boster Bio has a wide range of reagents and kits, including the Super Vision Detection Kits.

The ECL is a chemiluminescent method that detects proteins with a high level of expression. It is an alternative to traditional western blots. The Boster ECL is more sensitive than traditional colorimetric assays and can detect proteins that have a high or moderate level of expression. Researchers can monitor multiple proteins simultaneously with this technology. Boster ECL chemiluminescent detector system is extremely sensitive and allows them to detect multiple proteins at the same time.

The Boster Western Blotting Substrate is a luminol-based chemiluminescent substrate that detects horseradish peroxidase. It can be used in various blocking buffers and is compatible with nitrocellulose membranes. The system produces low background levels which makes it compatible with x-ray films and CCD imaging systems.

Hybond ECL, which is made of 100% pure nitrocellulose, is highly sensitive. Its low pore sizes and stable emission allow for multiple exposures and multiple blots within the same run. It is also made with a high-binding capacity. The Hybond ECL is compatible with proteins of all sizes. It can be used to analyze the molecularweight of proteins and their relative abundance.

Boster offers DAB, a chromogenic detection system

Boster Bio offers two types or chromogenic detector systems. These methods vary depending on which substances bind the secondary antibody. Boster ECL chemiluminescent detection system uses a solution containing a 4% Paraformaldehyde. This solution allows the secondary antigen to bind the samples, resulting in a color. DAB chromogenic detection uses a diluted solution.