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Product Info Summary
| SKU: | A02039 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, ICC, WB |
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Product info
Product Name
Anti-Toll-interacting protein TOLLIP Antibody
SKU/Catalog Number
A02039
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Toll-interacting protein TOLLIP Antibody (Catalog # A02039). Tested in ELISA, WB, IHC-P, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TOLLIP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Toll-interacting protein TOLLIP Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02039)
Host
Rabbit
Contents
TOLLIP Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TOLLIP antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human TOLLIP. The immunogen is located within the last 50 amino acids of TOLLIP.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
ERAP1 antibody is human and mouse reactive. At least two isoforms of ERAP1 are known to exist; this antibody will detect both isoforms. ERAP1 antibody is predicted to not cross-react with ERAP2.
Reactive Species
A02039 is reactive to TOLLIP in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
30282 MW
Background of TOLLIP
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02039 is guaranteed for ELISA, IF, IHC-P, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TOLLIP antibody can be used for the detection of TOLLIP by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL and immunocytochemistry starting at 2 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TOLLIP in rat brain cell lysate with TOLLIP antibody at (A) 1 and (B) 2 μg/mL.
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Immunocytochemistry of TOLLIP in THP-1 cells with TOLLIP antibody at 2 μg/mL.
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Immunofluorescence of TOLLIP in human brain tissue with TOLLIP antibody at 20 μg/ml.
Green: TOLLIP Antibody (A02039)
Blue: DAPI staining
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Immunohistochemistry of TOLLIP in human brain tissue with TOLLIP antibody at 5 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For TOLLIP (Source: Uniprot.org, NCBI)
Gene Name
TOLLIP
Full Name
Toll-interacting protein
Weight
30282 MW
Superfamily
tollip family
Alternative Names
IL-1RAcPIP, Toll-interacting protein TOLLIP IL-1RAcPIP toll interacting protein toll-interacting protein|adapter protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TOLLIP, check out the TOLLIP Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TOLLIP: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Toll-interacting protein TOLLIP Antibody (A02039)
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