Anti-TAB2 Antibody

Product Name

Anti-TAB2 Antibody

View all TAB2 Antibodies

SKU/Catalog Number

A02499

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-TAB2 Antibody (Catalog # A02499). Tested in ELISA, IHC-P applications. This antibody reacts with Human.

Storage & Handling

TAB2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-TAB2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02499)

Host

Rabbit

Contents

TAB2 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

TAB2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TAB2. The immunogen is located within the last 50 amino acids of TAB2.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

TAB2 antibody is human specific. TAB2 antibody is predicted not to cross-react with other TAB proteins.

Reactive Species

A02499 is reactive to TAB2 in Human

Reconstitution

Observed Molecular Weight

68 kDa

Calculated molecular weight

76494 MW

Background of TAB2

TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A02499 is guaranteed for ELISA, IHC-P Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

TAB2 antibody can be used for detection of TAB2 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For TAB2 (Source: Uniprot.org, NCBI)

Alternative Names

CHTD2, MAP3K7IP2, KIAA0733, TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAB-2 TAB2 CHTD2, MAP3K7IP2, TAB-2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2|TAK1-binding protein 2|mitogen-activated protein kinase kinase kinase 7-interacting protein 2

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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