TAB2 Antibodies

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2)

Adapter linking MAP3K7/TAK1 and TRAF6.

Promotes MAP3K7 activation in the IL1 signaling pathway.

The binding of'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 in'Thr-187'. Involved in heart development.

Gene Information

Human
Gene Name:	TAB2
Uniprot:	Q9NYJ8
Entrez:	23118

Family

Belongs to:
No superfamily

Alternative Names

FLJ21885; KIAA0733CHTD2; MAP3K7IP2mitogen-activated protein kinase kinase kinase 7 interacting protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAB-2; TAK1-binding protein 2; TGF-beta activated kinase 1/MAP3K7 binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2

Molecular Weight

Mass (kDA):
76.494 kDA

Genomic Context

Human
Location:	6q25.1
Sequence:	6; NC_000006.12 (149217924..149411613)

Tissue Specificity

Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.

Subcellular Localizations

Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Following IL1 stimulation, translocation occurs from the membrane to cytosol.

Diseases

• Malignant Neoplasms
• Inflammation
• Carcinoma
• Neoplasms
• Malignant Neoplasm Of Breast
• Diabetes Mellitus
• Dysplasia
• Rheumatoid Arthritis
• Arthritis
• Prostatic Neoplasms
• Ectodermal Dysplasia
• Mammary Neoplasms
• Autoimmune Reaction

• Bone Neoplasms
• Inflammatory Response
• Insulin Resistance
• Infective Disorder
• Autoimmune Diseases
• Diabetes Mellitus, Insulin-dependent
• Metaplastic Cell Transformation

Interacting Proteins

• BECN1
• FOSL1
• MAP3K7
• Map3k7
• TAB1

• TNIK
• TRAF6
• ZBTB16

Pathways

• Pathogenesis
• Localization
• Cell Death
• Autophagy
• Immune Response
• Translation
• Rna Interference
• Inflammatory Response
• Cell Cycle
• Mating
• Conjugation
• Cytokine Production
• Osteoclast Differentiation

• Response To Wounding
• Cell Migration
• Osteoblast Differentiation
• Dorsal Closure
• Cellular Homeostasis
• Fertilization
• Photosynthesis

PTMs

• Phosphorylation
• Ubiquitination
• Cleavage

• Sumoylation
• Dephosphorylation
• Reduction

• Methylation

Research Areas

• Cytokine Research
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TAB2

Boster Bio - Best Uses Of The TAB2 Marker

If you are looking for a monoclonal antibody that specifically targets the TAB2 protein, you might be interested in Boster Bio's Anti-TAB2 Monoclonal Antibody. In addition to offering high-affinity primary antibodies and secondary antibodies, Boster Bio offers various other options to help you perform a range of laboratory tests. Listed below are some of the benefits of using Boster antibodies.

Boster Bio Anti-TAB2 Monoclonal Antibody

Boster Bio offers monoclonal antibodies that have been validated on multiple platforms and are sourced from a wide variety of well-known cDNA libraries. The antibodies also have been validated on Western Blotting, Immunohistochemistry, and ELISA. If you are looking for an anti-TAB2 antibody, you can't go wrong with Boster.

The antibody reacts with the protein TAB2 in Human cells. It is stored at -20 degrees Celsius for one year and at 4°C for one month. It has a shelf life of a year and is available in a variety of commercial formats, such as PBS with 0.02% sodium azide. The antibody was raised against a synthetic peptide consisting of fourteen amino acids derived from the carboxy-terminal region of human TAB2 protein. Its cost varies depending on the length of the immunogen. Boster Bio validates each antibody by running it on positive and negative samples.

Boster offers high-affinity primary antibodies

Flow cytometry is a research method used to analyze the size, composition, and activity of biological samples. The primary sample consists of cells or particles. High-affinity primary antibodies are available from Boster Bio. These antibodies are available as monoclonal or polyclonal and have consistently received high citations throughout the scientific community. Many of the antibodies are used in research laboratories for a variety of applications, from cancer to neuroscience.

A diverse repertoire of high-affinity Abs is generated in the immune system and is continuously improved by ongoing immune responses. A recent study, based on human samples, has identified biological limits to repertoire diversification and affinity maturation induced by Ag. Two adult volunteers were vaccinated with tetanus toxoid three times and both underwent independent maturation. Moreover, the third vaccination caused no significant changes in the distribution of somatic mutations or binding rate constants. Fully matured Ab repertoires remained similar in size, genetically diverse, and dynamic.

In order to validate the specificity of an antibody, it must be tested in a variety of cell types and tissues. Ideally, antibodies should yield no signal when tested against a knockout or reduced expression of the target protein. However, when testing antibodies by WB, it is important to consider the biochemical properties of the target protein. Antibodies are highly specific if they yield a signal only when tested against the predicted molecular weight.

Boster offers high-affinity secondary antibodies

Boster Bio produces picogram-sensitive ELISA kits and IHC-optimized polyclonal antibodies. Their product range includes over 12,000 antibodies and is validated for use in IHC, Flow, and WB. They are tested against a panel of 250 different tissues, and are quantitatively validated against known concentrations of recombinant proteins. They are also available through tebu-bio.

Primary and secondary antibodies are derived from the same source. Both antibodies bind to a specific antigen or protein. Secondary antibodies bind to the same antigen. Boster offers high-affinity primary antibodies in both polyclonal and monoclonal forms. They have a long history of publication and continue to be cited as excellent products. In addition to monoclonal antibodies, Boster offers polyclonal and chimeric secondary antibodies.

A pre-adsorption step increases the specificity of a secondary antibody and minimizes non-specific binding. The antibodies are then passed through a column of immobilized proteins. The reactive antibodies bind to the proteins and non-reactive antibodies flow through. Ultimately, a high-affinity secondary antibody improves the precision of your experiments. These antibodies also have high affinity for a wide range of biological targets.

Besides the high-affinity primary antibodies, Boster Bio also provides custom service to meet your needs. They offer rabbit and chicken polyclonal antibodies and monoclonal antibodies. Apart from custom antibody manufacturing, they also provide monoclonal antibodies, recombinant proteins, and multicolor cocktails. And finally, you can work with custom-made antibodies at the highest quality and with the lowest cost.

Depending on your needs, you can choose the best product according to your research needs. Boster Bio offers a range of high-affinity secondary antibodies to help your research. In addition to primary antibodies, they also offer recombinant secondary antibodies to boost research results. These antibodies are highly useful for immunological studies. In addition to boosting the effectiveness of your research, high-affinity antibodies are available for a variety of applications.

When choosing secondary antibodies, you must be sure that the primary antibody matches the desired species. For instance, if you're using mouse primary antibodies, you'll need a secondary antibody that recognizes mouse IgG2a. Likewise, if you are using multiple primary antibodies, you'll need to choose specific secondary antibodies for the experiment. In such a case, you can work with Novus Biologicals' Technical Support team for assistance.