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TAB2 Antibodies
AND TAB2 ELISA kits, TAB2 Proteins
Many biological assays use antibodies to detect TAB2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TAB2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TAB2 antibodies...
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TAB2 Overview
Facts about TGF-beta-activated kinase 1 and MAP3K7-binding protein 2.
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (TAB2)
Adapter linking MAP3K7/TAK1 and TRAF6.
Promotes MAP3K7 activation in the IL1 signaling pathway.The binding of'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 in'Thr-187'. Involved in heart development.
Gene Information
| Human | |
|---|---|
| Gene Name: | TAB2 |
| Uniprot: | Q9NYJ8 |
| Entrez: | 23118 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FLJ21885; KIAA0733CHTD2; MAP3K7IP2mitogen-activated protein kinase kinase kinase 7 interacting protein 2; Mitogen-activated protein kinase kinase kinase 7-interacting protein 2; TAB-2; TAK1-binding protein 2; TGF-beta activated kinase 1/MAP3K7 binding protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; TGF-beta-activated kinase 1-binding protein 2
Molecular Weight
Mass (kDA):
76.494 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q25.1 |
| Sequence: | 6; NC_000006.12 (149217924..149411613) |
Tissue Specificity
Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.
Subcellular Localizations
Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Following IL1 stimulation, translocation occurs from the membrane to cytosol.
Diseases
- Malignant Neoplasms
- Inflammation
- Carcinoma
- Neoplasms
- Malignant Neoplasm Of Breast
- Diabetes Mellitus
- Dysplasia
- Rheumatoid Arthritis
- Arthritis
- Prostatic Neoplasms
- Ectodermal Dysplasia
- Mammary Neoplasms
- Autoimmune Reaction
Interacting Proteins
- BECN1
- FOSL1
- MAP3K7
- Map3k7
- TAB1
- TNIK
- TRAF6
- ZBTB16
Pathways
- Pathogenesis
- Localization
- Cell Death
- Autophagy
- Immune Response
- Translation
- Rna Interference
- Inflammatory Response
- Cell Cycle
- Mating
- Conjugation
- Cytokine Production
- Osteoclast Differentiation
PTMs
- Phosphorylation
- Ubiquitination
- Cleavage
Research Areas
- Cytokine Research
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TAB2
bosterbio.com/bosterbio-gene-info-cards/TAB2
References
PMID: 10882101 by Takaesu G., et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.
PMID: 11460167 by Wang C., et al. TAK1 is a ubiquitin-dependent kinase of MKK and IKK.