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Product Info Summary
| SKU: | A05419 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Chicken |
| Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-SIVA SIVA1 Antibody
SKU/Catalog Number
A05419
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-SIVA SIVA1 Antibody (Catalog # A05419). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse.
Storage & Handling
SIVA antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-SIVA SIVA1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05419)
Host
Chicken
Contents
SIVA Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgY
Immunogen
SIVA antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SIVA. The immunogen is located within the first 50 amino acids of SIVA.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A05419 is reactive to SIVA1 in Human, Mouse
Applications
A05419 is guaranteed for ELISA, IF, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
18695 MW
Background of SIVA
SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure. The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway. SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFκ-B and promotes T-cell receptor-mediated apoptosis. SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SIVA antibody can be used for detection of EPAC1 by Western blot at 1 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SIVA in mouse liver tissue lysate with SIVA antibody at 1 μg/mL.
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Immunofluorescence of SIVA in mouse liver cells with SIVA antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SIVA1 (Source: Uniprot.org, NCBI)
Gene Name
SIVA1
Full Name
Apoptosis regulatory protein Siva
Weight
18695 MW
Alternative Names
CD27-binding (Siva) protein; CD27BPCD27-binding protein; Siva-1; SIVA1, apoptosis-inducing factor; Siva-2; SIVAapoptosis regulatory protein Siva SIVA1 CD27BP, SIVA, Siva-1, Siva-2 SIVA1 apoptosis inducing factor apoptosis regulatory protein Siva|CD27-binding (Siva) protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SIVA1, check out the SIVA1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SIVA1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-SIVA SIVA1 Antibody (A05419)
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