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SIVA1 Antibodies
AND SIVA1 ELISA kits, SIVA1 Proteins
Many biological assays use antibodies to detect SIVA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SIVA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SIVA1 antibodies...
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SIVA1 Infographic by Boster Bio
All SIVA1 Products
Product
Figures
Specificity
Applications
Price
Human
IF, IHC, WB
$523
Cat # M05419
100 µl
Cat # M05419
100 µl
SIVA1 Overview
Facts about Apoptosis regulatory protein Siva.
Apoptosis regulatory protein Siva (SIVA1)
Induces CD27-mediated apoptosis.
Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity.Inhibits activation of NF-kappa- B and boosts T-cell receptor-mediated apoptosis. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SIVA1 |
| Uniprot: | O15304 |
| Entrez: | 10572 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD27-binding (Siva) protein; CD27BPCD27-binding protein; Siva-1; SIVA1, apoptosis-inducing factor; Siva-2; SIVAapoptosis regulatory protein Siva
Molecular Weight
Mass (kDA):
18.695 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q32.33 |
| Sequence: | 14; NC_000014.9 (104752420..104759659) |
Tissue Specificity
Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.
Subcellular Localizations
Cytoplasm. Nucleus. In the nucleus, accumulates in dot-like structures.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Myocarditis
- Coxsackievirus Infections
- Familial Mediterranean Fever
- Mammary Neoplasms
- Brucellosis
- Inflammation
- Infective Disorder
- Instabilities, Chromosomal
- Neoplasm Metastasis
- Neoplasms, Experimental
Interacting Proteins
- BCL2
- BCL2L1
- CD27
- PXMP2
Pathways
- Cell Death
- Pathogenesis
- Induction Of Apoptosis
- Cell Growth
- Programmed Cell Death
- Response To Oxidative Stress
- Cell Proliferation
- Cell Activation
- Cell Migration
- T Cell Activation
- Immune Response
- Embryo Development
- Phagocytosis
PTMs
- Phosphorylation
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIVA1
bosterbio.com/bosterbio-gene-info-cards/SIVA1
References
PMID: 9177220 by Prasad K.V.S., et al. CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.
PMID: 10756043 by Henke A., et al. Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva.