Anti-E3 SUMO-protein ligase PIAS3 PIAS3 Antibody

Product Name

Anti-E3 SUMO-protein ligase PIAS3 PIAS3 Antibody

View all PIAS3 Antibodies

SKU/Catalog Number

A02807

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-E3 SUMO-protein ligase PIAS3 PIAS3 Antibody (Catalog # A02807). Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-E3 SUMO-protein ligase PIAS3 PIAS3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02807)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from Internal of human PIAS3.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02807 is reactive to PIAS3 in Human, Mouse, Rat

Applications

A02807 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

68017 MW

Background of PIAS3

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth.

Jiang-Hong Man, Nucleic Acids Res., Nov 2006; 34: 5552 - 5566.
Amir Sonnenblick, Mol. Cell. Biol., Dec 2004; 24: 10584 - 10592.
Jianyin Long, PNAS, Jan 2004; 101: 99.
Hyun Duk Jang, J. Biol. Chem., Jun 2004; 279: 24873 - 24880.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Validation Images & Assay Conditions

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Western blot analysis of extracts from 293 cells, treated with UV (5mins), using PIAS3 antibody A02807.

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Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using PIAS3 antibody A02807.

Gene/Protein Information For PIAS3 (Source: Uniprot.org, NCBI)

Alternative Names

MIZ-type containing 5; PIAS3; Protein inhibitor of activated STAT protein 3; protein inhibitor of activated STAT, 3; ZMIZ5 PIAS3 ZMIZ5 protein inhibitor of activated STAT 3 E3 SUMO-protein ligase PIAS3|E3 SUMO-protein transferase PIAS3|protein inhibitor of activated STAT protein 3|zinc finger, MIZ-type containing 5

For more info on PIAS3, check out the PIAS3 Infographic

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In this infographic, you will see the following information for PIAS3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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