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Product Info Summary
| SKU: | A02807 |
|---|---|
| Size: | 100 µl |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | IHC, WB |
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Product info
Product Name
Anti-E3 SUMO-protein ligase PIAS3 PIAS3 Antibody
SKU/Catalog Number
A02807
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-E3 SUMO-protein ligase PIAS3 PIAS3 Antibody (Catalog # A02807). Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-E3 SUMO-protein ligase PIAS3 PIAS3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02807)
Host
Rabbit
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from Internal of human PIAS3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A02807 is reactive to PIAS3 in Human, Mouse, Rat
Reconstitution
Calculated molecular weight
68017 MW
Background of PIAS3
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth.
Jiang-Hong Man, Nucleic Acids Res., Nov 2006; 34: 5552 - 5566.
Amir Sonnenblick, Mol. Cell. Biol., Dec 2004; 24: 10584 - 10592.
Jianyin Long, PNAS, Jan 2004; 101: 99.
Hyun Duk Jang, J. Biol. Chem., Jun 2004; 279: 24873 - 24880.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02807 is guaranteed for IHC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Validation Images & Assay Conditions
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Western blot analysis of extracts from 293 cells, treated with UV (5mins), using PIAS3 antibody A02807.
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Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using PIAS3 antibody A02807.
Protein Target Info & Infographic
Gene/Protein Information For PIAS3 (Source: Uniprot.org, NCBI)
Gene Name
PIAS3
Full Name
E3 SUMO-protein ligase PIAS3
Weight
68017 MW
Superfamily
PIAS family
Alternative Names
E3 SUMO-protein ligase PIAS3;6.3.2.-;Protein inhibitor of activated STAT protein 3;PIAS3; PIAS3 ZMIZ5 protein inhibitor of activated STAT 3 E3 SUMO-protein ligase PIAS3|E3 SUMO-protein transferase PIAS3|protein inhibitor of activated STAT protein 3|zinc finger, MIZ-type containing 5
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PIAS3, check out the PIAS3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PIAS3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-E3 SUMO-protein ligase PIAS3 PIAS3 Antibody (A02807)
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