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Product Info Summary
| SKU: | PA1968 |
|---|---|
| Size: | 100 μg/vial |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | IHC, WB |
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Product info
Product Name
Anti-LTBR Antibody Picoband®
View all Lymphotoxin beta R/TNFRSF3 Antibodies
SKU/Catalog Number
PA1968
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-LTBR Antibody catalog # PA1968. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-LTBR Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1968)
Host
Rabbit
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human LTBR.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
PA1968 is reactive to LTBR in Human
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Observed Molecular Weight
60 kDa
Calculated molecular weight
46709 MW
Background of Lymphotoxin beta R/TNFRSF3
LTBR (Lymphotoxin B Receptor), also called TNFCR or LT-BETA-R, is a receptor for lymphotoxin which in humans is encoded by the LTBR gene. By linkage analysis with recombinant inbred mouse strains, Nakamura et al. (1995) demonstrated that the Tnfcr locus is close to the Tnfr1 gene on mouse chromosome 6. Presumably, the human homolog is located on 12p13. Silva-Santos et al. (2005) reported that double-positive T cells regulate the differentiation of early thymocyte progenitors and gamma-delta cells by a mechanism dependent on the transcription factor ROR-gamma-t and the lymphotoxin-beta receptor. Lo et al. (2007) identified lymphotoxin and LIGHT (TNFSF14), tumor necrosis factor cytokine family members that are primarily expressed on lymphocytes, as critical regulators of key enzymes that control lipid metabolism.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
PA1968 is guaranteed for IHC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, By Heat
Western blot, 0.1-0.5μg/ml, Human
Positive Control
WB: HELA Whole Cell, A549 Whole Cell
IHC: Human Intestinal Cancer Tissue
Validation Images & Assay Conditions
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Anti-LTBR antibody, PA1968, IHC(P)
IHC(P): Human Intestinal Cancer Tissue
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Anti-LTBR antibody, PA1968, Western blotting
All lanes: Anti LTBR (PA1968) at 0.5ug/ml
Lane 1: HELA Whole Cell Lysate at 40ug
Lane 2: A549 Whole Cell Lysate at 40ug
Predicted bind size: 47KD
Observed bind size: 60KD
Protein Target Info & Infographic
Gene/Protein Information For LTBR (Source: Uniprot.org, NCBI)
Gene Name
LTBR
Full Name
Tumor necrosis factor receptor superfamily member 3
Weight
46709 MW
Alternative Names
Tumor necrosis factor receptor superfamily member 3;Lymphotoxin-beta receptor;Tumor necrosis factor C receptor;Tumor necrosis factor receptor 2-related protein;Tumor necrosis factor receptor type III;TNF-RIII;TNFR-III;LTBR;D12S370, TNFCR, TNFR3, TNFRSF3; LTBR D12S370, LT-BETA-R, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFR3, TNFRSF3 lymphotoxin beta receptor tumor necrosis factor receptor superfamily member 3|lymphotoxin B receptor|lymphotoxin beta receptor (TNFR superfamily, member 3)|tumor necrosis factor C receptor|tumor necrosis factor receptor 2-related protein|tumor necrosis factor receptor type III
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on LTBR, check out the LTBR Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for LTBR: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-LTBR Antibody Picoband® (PA1968)
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Customer Reviews
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Customer Q&As
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3 Customer Q&As for Anti-LTBR Antibody Picoband®
Question
you antibody to test anti-LTBR antibody PA1968 on human cervix carcinoma for research purposes, then I may be interested in using anti-LTBR antibody PA1968 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?
Verified Customer
Verified customer
Asked: 2019-08-23
Answer
The products we sell, including anti-LTBR antibody PA1968, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.
Boster Scientific Support
Answered: 2019-08-23
Question
We are currently using anti-LTBR antibody PA1968 for human tissue, and we are satisfied with the WB results. The species of reactivity given in the datasheet says human. Is it possible that the antibody can work on goat tissues as well?
Verified Customer
Verified customer
Asked: 2019-03-08
Answer
The anti-LTBR antibody (PA1968) has not been validated for cross reactivity specifically with goat tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in goat you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2019-03-08
Question
Here is the WB image, lot number and protocol we used for cervix carcinoma using anti-LTBR antibody PA1968. Please let me know if you require anything else.
Verified Customer
Verified customer
Asked: 2017-11-21
Answer
Thank you very much for the data. Our lab team are working to resolve this as quickly as possible, and we appreciate your patience and understanding! You have provided everything we needed. Please let me know if there is anything you need in the meantime.
Boster Scientific Support
Answered: 2017-11-21
