Anti-Kv1.4/KCNA4 Antibody

Product Name

Anti-Kv1.4/KCNA4 Antibody

View all Kv1.4 Antibodies

SKU/Catalog Number

PA2297

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Kv1.4/KCNA4 Antibody catalog # PA2297. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Kv1.4/KCNA4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2297)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Kv1.4, different from the related mouse and rat sequences by one amino acid.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA2297 is reactive to KCNA4 in Human, Mouse, Rat

Applications

PA2297 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

70 kDa

Calculated molecular weight

73257 MW

Background of Kv1.4

Potassium voltage-gated channel subfamily A member 4, also known as Kv1.4 or PCN2, is a protein that in humans is encoded by the KCNA4 gene. This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. It is mapped to 11p14.1. KCNA4 belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential. KCNA4 also contributes to the cardiac transient outward potassium current (Ito1), the main contributing current to the repolarizing phase 1 of the cardiac action potential. This gene has been shown to interact with DLG4, KCNA2 and DLG1.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse

Validation Images & Assay Conditions

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Anti-Kv1.4 antibody, PA2297, All Western blotting
All lanes: Anti-KCNA4(PA2297) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 40ug
Lane 2: HY1080Whole Cell Lysate at 40ug
Lane 3: PANC Whole Cell Lysate at 40ug
Lane 4: U87 Whole Cell Lysate at 40ug
Lane 5: SHG Whole Cell Lysate at 40ug
Predicted bind size: 70KD
Observed bind size: 70KD

Gene/Protein Information For KCNA4 (Source: Uniprot.org, NCBI)

Alternative Names

cardiac potassium channel; fetal skeletal muscle potassium channel; HBK4; HK1; HPCN2HUKII; KCNA4L; KCNA8; KV1.4; PCN2; potassium channel 2; potassium voltage-gated channel subfamily A member 4; potassium voltage-gated channel, shaker-related subfamily, member 4; potassium voltage-gated channel, shaker-related subfamily, member 4-like; rapidly inactivating potassium channel; shaker-related potassium channel Kv1.4; type A potassium channel; Voltage-gated K(+) channel HuKII; Voltage-gated potassium channel HBK4; Voltage-gated potassium channel HK1; Voltage-gated potassium channel subunit Kv1.4 KCNA4 HBK4, HK1, HPCN2, HUKIIL, KCNA8, KV1.4, MCIDDS, PCN2, KCNA4 potassium voltage-gated channel subfamily A member 4 potassium voltage-gated channel subfamily A member 4|cardiac potassium channel|fetal skeletal muscle potassium channel|potassium channel 2|potassium channel, voltage gated shaker related subfamily A, member 4|rapidly inactivating potassium channel|shaker-related potassium channel Kv1.4|type A potassium channel|voltage-gated K(+) channel HuKII|voltage-gated potassium channel HBK4|voltage-gated potassium channel HK1|voltage-gated potassium channel subunit Kv1.4

For more info on KCNA4, check out the KCNA4 Infographic

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In this infographic, you will see the following information for KCNA4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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