KCNA4 Antibodies

Potassium voltage-gated channel subfamily A member 4 (KCNA4)

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient.

The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties are based on the sort of alpha subunits that are part of the channel (PubMed:8495559).

Gene Information

Human
Gene Name:	KCNA4
Uniprot:	P22459
Entrez:	3739

Family

Belongs to:
potassium channel family

Alternative Names

cardiac potassium channel; fetal skeletal muscle potassium channel; HBK4; HK1; HPCN2HUKII; KCNA4L; KCNA8; KV1.4; PCN2; potassium channel 2; potassium voltage-gated channel subfamily A member 4; potassium voltage-gated channel, shaker-related subfamily, member 4; potassium voltage-gated channel, shaker-related subfamily, member 4-like; rapidly inactivating potassium channel; shaker-related potassium channel Kv1.4; type A potassium channel; Voltage-gated K(+) channel HuKII; Voltage-gated potassium channel HBK4; Voltage-gated potassium channel HK1; Voltage-gated potassium channel subunit Kv1.4

Molecular Weight

Mass (kDA):
73.257 kDA

Genomic Context

Human
Location:	11p14.1
Sequence:	11; NC_000011.10 (30009730..30017030, complement)

Tissue Specificity

Detected in heart ventricle.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell projection, axon.

Diseases

• Neoplasms
• Heart Diseases
• Hypertrophy
• Cardiac Arrhythmia
• Infarction
• Myocardial Infarction
• Nervousness
• Heart Block
• Pituitary Diseases
• Chimera Disorder
• Diabetes Mellitus
• Cardiac Fibrillation
• Epilepsy

• Diabetes Mellitus, Non-insulin-dependent
• Chronic Atrial Fibrillation
• Atrial Fibrillation
• Tachycardia, Ventricular
• Stomach Neoplasms
• Spinal Cord Injuries
• Ataxia

Interacting Proteins

• Dlg3
• DLG4
• Dlg4
• SAT1

Pathways

• Localization
• Glycosylation
• Transport
• Secretion
• Protein Phosphorylation
• Membrane Depolarization
• Translation
• Insulin Secretion
• Endocytosis
• Regulation Of Insulin Secretion
• Glial Cell Proliferation
• Developmental Maturation
• Cell Division

• Reverse Transcription
• Cell Cycle
• Rna Folding
• Wound Healing
• Schwann Cell Development
• Exocytosis
• Cell Proliferation

PTMs

• Phosphorylation
• Glycosylation
• Palmitoylation

• Biotinylation
• Phosphorothioation
• Methylation

• Acylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNA4

Best Uses Of The KCNA4 Marker

A high-affinity KCNA4 antibody is crucial when it comes to determining which protein should be used. Boster has many products to choose from, including the anti-KCNN4 antibody and high-affinity primary antibodies. Boster also offers secondary antibodies. Find out more about the various uses of this protein as well as how it can assist you in your research.

Boster offers primary antibodies with high affinity

The potassium channel KCNA4 binds with the phosphorylated version of sodium. This phosphorylated form of sodium is detected by antibodies that bind to it. The Picoband(tm), Boster Bio AntiKv1.1 antibody catalog is available. It has been tested and validated in ELISA, Immunohistochemistry, and Western Blotting methods.

These primary antibodies can be made from the immunoglobulin sequencing of various antigens. This involves immunizations of experimental animals, fusion of antibody-producing cell lines, and screening for specificities. The antibodies can be generated from phage display or naive synthetic antibody libraries. Various types of peptides are used for antibody generation.

Boster sells anti-KCNN4 anti-KCN4 antibody

Many suppliers offer anti KCNN4 anti-KCN4 antibodies. These antibodies are specific for the potassium calcium-activated channel subfamily N member 4. This protein is also known by many other names, such as KCa3.1, DHS2, IK, and intermediate conductance calcium-activated potassium channel protein. There are many antibodies available for this protein in orthologs, which can be found in canine, mouse and rats.

Boster Bio has a range of excellent products for you, whether you need an anti-KCNN4 antibody for IHC or ELISA. Their antibody range consists of more than 12,000 antibodies and is fully validated for IHC, WB, and Flow. All Boster Bio antibodies are quantitatively tested for specificity against a panel of tissues and untransfected cell lines.

Anti-KCNN4 antibody makes it easy to perform Western blot analyses. This antibody is highly sensitive and can be used in a wide range of research applications. Boster Bio offers two options for ordering your antibody: either online or in person. Boster Bio has been providing high quality antibodies for more than 30 years. The company's customer service team is always available to answer any questions.

Boster offers secondary antibodies with high-affinity

Boster Bio has an antibody to measure a specific peptide, or protein. These antibodies have been tested for high-affinity and high-specificity in Western Blotting and immunohistochemistry. You can also order a Liquid anti-IP. No matter if you're looking for an antibody to test an anti-infected reaction or conducting research for personal use, you can find the right reagent.

Primary antibodies are immunoglobulins which bind to a target antigen. They are graded by their specificity and affinity, two important properties. The affinity refers to the amount unintended binding that secondary antibodies can show, while the former is more important in determining secondary antibody affinity. A good primary antibody is useful for detecting, measuring, purifying, and analyzing the antigen of interest.

Secondary antibodies can be used to complement primary antibodies. Their ability to bind antigens makes them a crucial part of many experiments and assays. The most common immunoassays use antibodies to measure cellular responses to a given antigen. Other popular methods of immunoassays include Western Blotting, immunohistochemistry, and immunofluorescence. Another popular method of measuring cell types is flowcytometry.