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Product Info Summary
| SKU: | A03354 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-IPR1 SP110 Antibody
SKU/Catalog Number
A03354
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-IPR1 SP110 Antibody (Catalog # A03354). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
IPR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-IPR1 SP110 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03354)
Host
Rabbit
Contents
IPR1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
IPR1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human IPR1. The immunogen is located within amino acids 470 - 520 of IPR1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms are known to exist. This antibody is predicted to not cross-react with LMX1A.
Reactive Species
A03354 is reactive to SP110 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
78396 MW
Background of SP110
Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03354 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Ipr1 antibody can be used for detection of Ipr1 by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of IPR1 in Hela cell lysate with IPR1 antibody at (A) 0.5
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Immunohistochemical staining of human brain tissue using IPR1 antibody at 2.5 μg/mL.
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Immunofluorescence of IPR1 in Human Brain cells with IPR1 antibody at 50 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SP110 (Source: Uniprot.org, NCBI)
Gene Name
SP110
Full Name
Sp110 nuclear body protein
Weight
78396 MW
Alternative Names
IPR1, VODI, IFI41, IFI75, Sp110 nuclear body protein, Speckled 110 kDa SP110 IFI41, IFI75, IPR1, VODI SP110 nuclear body protein sp110 nuclear body protein|interferon-induced protein 41, 30kD|interferon-induced protein 41/75|interferon-induced protein 75, 52kD|phosphoprotein 41|phosphoprotein 75|speckled 110 kDa|transcriptional coactivator Sp110
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SP110, check out the SP110 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SP110: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-IPR1 SP110 Antibody (A03354)
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