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Product Info Summary
| SKU: | A04024 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-Importin subunit alpha-5 KPNA1 Antibody
View all Importin alpha 5/KPNA1/SRP1 Antibodies
SKU/Catalog Number
A04024
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Importin subunit alpha-5 KPNA1 Antibody (Catalog # A04024). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
KPNA1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Importin subunit alpha-5 KPNA1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04024)
Host
Rabbit
Contents
KPNA1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
KPNA1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human KPNA1. The immunogen is located within amino acids 30 - 80 of KPNA1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
ADRM1 antibody is human, mouse and rat reactive. At least two isoforms of ADRM1 are know to exist; this antibody will detect both isoforms.
Reactive Species
A04024 is reactive to KPNA1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
60222 MW
Background of Importin alpha 5/KPNA1/SRP1
Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA1, also known as importin alpha 5, is the alpha subunit of karyopherin, which forms a complex with importin subunit beta-1 and functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. It is ubiquitously expressed and polyubiquitinated in the presence of RAG1. KPNA1 interacts with various virus nucleoproteins, including those of Ebola and influenza.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A04024 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
KPNA1 antibody can be used for detection of KPNA1 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of KPNA1 in Hela cell lysate with KPNA1 antibody at 1μg/mL.
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Immunocytochemistry of KPNA1 in HeLa cells with KPNA1 antibody at 2.5 μg/mL.
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Immunofluorescence of KPNA1 in K562 cells with KPNA1 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For KPNA1 (Source: Uniprot.org, NCBI)
Gene Name
KPNA1
Full Name
Importin subunit alpha-5
Weight
60222 MW
Superfamily
importin alpha family
Alternative Names
RCH2, SRP1, IPOA5, NPI-1, RCH2, Importin subunit alpha-5, Karyopherin subunit alpha-1 KPNA1 IPOA5, NPI-1, RCH2, SRP1 karyopherin subunit alpha 1 importin subunit alpha-5|RAG cohort protein 2|SRP1-beta|importin alpha 5|importin subunit alpha-1|importin-alpha-S1|karyopherin alpha 1 (importin alpha 5)|nucleoprotein interactor 1|recombination activating gene cohort 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on KPNA1, check out the KPNA1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for KPNA1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Importin subunit alpha-5 KPNA1 Antibody (A04024)
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