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Product Info Summary
| SKU: | M11385 |
|---|---|
| Size: | 100ug/vial |
| Reactive Species: | Human |
| Host: | Mouse |
| Application: | IHC |
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Product info
Product Name
Anti-IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) Monoclonal Antibody
View all Ig gamma-4 Chain C Region Antibodies
SKU/Catalog Number
M11385
Size
100ug/vial
Form
Liquid
Description
Boster Bio Anti-IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) Monoclonal Antibody (Catalog # M11385). Tested in IHC applications. This antibody reacts with Human.
Storage & Handling
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Cite This Product
Anti-IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M11385)
Host
Mouse
Contents
Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Clonality
Monoclonal
Clone Number
Clone: IGHG4/1345
Isotype
IgG1, kappa
Immunogen
Recombinant human IGHG4 fragment
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Does not cross-react with primate, avian or amphibian GR.
Reactive Species
M11385 is reactive to IGHG4 in Human
Reconstitution
Reconstitute with distilled water.
Observed Molecular Weight
68 kDa
Calculated molecular weight
35941 MW
Background of Ig gamma-4 Chain C Region
The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells.IgG4 is overexpressed in inflammatory pseudotumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M11385 is guaranteed for IHC Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
Validation Images & Assay Conditions
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Formalin-fixed, paraffin-embedded human Tonsil stained with Anti-IgG4 Mouse Monoclonal Antibody (IGHG4/1345).
Protein Target Info & Infographic
Gene/Protein Information For IGHG4 (Source: Uniprot.org, NCBI)
Gene Name
IGHG4
Full Name
Immunoglobulin heavy constant gamma 4
Weight
35941 MW
Alternative Names
Ig gamma-4 chain C region;IGHG4; IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker) immunoglobulin heavy chain constant region gamma 4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on IGHG4, check out the IGHG4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for IGHG4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) Monoclonal Antibody (M11385)
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