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Product Info Summary
| SKU: | A05518 |
|---|---|
| Size: | 100 µl |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | IHC, WB |
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Product info
Product Name
Anti-Cytochrome P450 8B1 CYP8B1 Antibody
SKU/Catalog Number
A05518
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-Cytochrome P450 8B1 CYP8B1 Antibody (Catalog # A05518). Tested in WB, IHC applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Cytochrome P450 8B1 CYP8B1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05518)
Host
Rabbit
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from internal of human Cytochrome P450 8B1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A05518 is reactive to CYP8B1 in Human
Reconstitution
Observed Molecular Weight
111 kDa
Calculated molecular weight
58068 MW
Background of CYP8B1
Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids.
Gaafvels M., Genomics 56:184-196(1999).
Ota T., Nat. Genet. 36:40-45(2004).
Muzny D.M., Nature 440:1194-1198(2006)
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A05518 is guaranteed for IHC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Validation Images & Assay Conditions
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Western blot analysis of extracts from 293 cells, using Cytochrome P450 8B1 antibody A05518.
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Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using Cytochrome P450 8B1 antibody A05518.
Protein Target Info & Infographic
Gene/Protein Information For CYP8B1 (Source: Uniprot.org, NCBI)
Gene Name
CYP8B1
Full Name
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Weight
58068 MW
Superfamily
cytochrome P450 family
Alternative Names
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase;1.14.18.8 ;7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase;CYPVIIIB1;Cytochrome P450 8B1;Sterol 12-alpha-hydroxylase;CYP8B1;CYP12; CYP8B1 CP8B, CYP12 cytochrome P450 family 8 subfamily B member 1 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase|7 alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase|CYPVIIIB1|cytochrome P450 8B1|cytochrome P450, family 8, subfamily B, polypeptide 1|cytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1|sterol 12-alpha-hydroxylase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CYP8B1, check out the CYP8B1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CYP8B1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Cytochrome P450 8B1 CYP8B1 Antibody (A05518)
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No publications found for A05518
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