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Product Info Summary
| SKU: | A14323 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-SIGLEC15 Antibody
SKU/Catalog Number
A14323
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-SIGLEC15 Antibody (Catalog # A14323). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
SIGLEC15 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-SIGLEC15 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A14323)
Host
Rabbit
Contents
SIGLEC15 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
SIGLEC15 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human SIGLEC15. The immunogen is located within amino acids 50 - 100 of SIGLEC15.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
SIGLEC15 antibody is predicted to not cross-react with other SIGLEC family members.
Reactive Species
A14323 is reactive to SIGLEC15 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
35653 MW
Background of Siglec-15
Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig)-like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A14323 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
SIGLEC15 antibody can be used for detection of SIGLEC15 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of SIGLEC15 in human kidney tissue lysate with SIGLEC15 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of SIGLEC15 in human kidney tissue with SIGLEC15 antibody at 2.5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For SIGLEC15 (Source: Uniprot.org, NCBI)
Gene Name
SIGLEC15
Full Name
Sialic acid-binding Ig-like lectin 15
Weight
35653 MW
Superfamily
immunoglobulin superfamily
Alternative Names
CD33L3, HsT1361, SIGLEC-15, CD33L3, Sialic acid-binding Ig-like lectin 15, CD33 antigen-like 3, Siglec-15 SIGLEC15 CD33L3, HsT1361, SIGLEC-15 sialic acid binding Ig like lectin 15 sialic acid-binding Ig-like lectin 15|CD33 -like 3|CD33 molecule-like 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on SIGLEC15, check out the SIGLEC15 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for SIGLEC15: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-SIGLEC15 Antibody (A14323)
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