Product Info Summary
SKU: | A00339 |
---|---|
Size: | 100 µl |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | IHC, WB |
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Product info
Product Name
Anti-Cytochrome P450 3A4 CYP3A4 Antibody
SKU/Catalog Number
A00339
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-Cytochrome P450 3A4 CYP3A4 Antibody (Catalog # A00339). Tested in WB, IHC applications. This antibody reacts with Human, Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Cytochrome P450 3A4 CYP3A4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00339)
Host
Rabbit
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from internal of human Cytochrome P450 3A4.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A00339 is reactive to CYP3A4 in Human, Mouse
Applications
A00339 is guaranteed for IHC, WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
57343 MW
Background of CYP3A4
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Vuoristo M.M., J. Biol. Chem. 270:22873-22881(1995).
Mungall A.J., Nature 425:805-811(2003).
Lui V.C., Genomics 32:401-412(1996).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of extracts from K562 cells, using P450 3A4 antibody A00339.
Click image to see more details
Immunohistochemistry analysis of paraffin-embedded human brain tissue using Cytochrome P450 3A4 antibody A00339.
Protein Target Info & Infographic
Gene/Protein Information For CYP3A4 (Source: Uniprot.org, NCBI)
Gene Name
CYP3A4
Full Name
Cytochrome P450 3A4
Weight
57343 MW
Superfamily
cytochrome P450 family
Alternative Names
Albendazole Monooxygenase; Albendazole Sulfoxidase; CP33; CP34; CYP3A; CYP3A3; CYP3A4; CYPIIIA3; CYPIIIA4; Cytochrome P450 3A3; cytochrome P450 3A4; Cytochrome P450 HLp; Cytochrome P450 NF-25; cytochrome P450, family 3, subfamily A, polypeptide 4; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; Cytochrome P450-PCN1; EC 1.14.13.32; EC 1.14.13.67; EC 1.14.13.97; EC 1.14.14.1; glucocorticoid-inducible P450; HLP; MGC126680; NF-25; Nifedipine oxidase; P450C3; P450-III, steroid inducible; P450PCN1; Quinine 3- CYP3A4 CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1, VDDR3 cytochrome P450 family 3 subfamily A member 4 cytochrome P450 3A4|1,4-cineole 2-exo-monooxygenase|1,8-cineole 2-exo-monooxygenase|P450-III, steroid inducible|albendazole monooxygenase (sulfoxide-forming)|albendazole sulfoxidase|cholesterol 25-hydroxylase|cytochrome P450 3A3|cytochrome P450 HLp|cytochrome P450 NF-25|cytochrome P450, family 3, subfamily A, polypeptide 4|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4|cytochrome P450-PCN1|glucocorticoid-inducible P450|nifedipine oxidase|quinine 3-monooxygenase|taurochenodeoxycholate 6-alpha-hydroxylase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CYP3A4, check out the CYP3A4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CYP3A4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Cytochrome P450 3A4 CYP3A4 Antibody (A00339)
Hello CJ!
A00339 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Involvement of NF-κB in the reversal of CYP3A down-regulation induced by sea buckthorn in BCG-induced rats
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