Key=store_id Key=entity_id, value=54508 Key=attribute_set_id, value=4 Key=type_id, value=simple Key=sku, value=EKC2072 Key=has_options, value=0 Key=required_options, value=0 Key=created_at, value=2019-02-12 00:21:00 Key=updated_at, value=2024-09-26 01:01:48 Key=mst_search_weight, value=0 Key=status, value=Enabled Key=name, value=FOXO1A (Phospho-Ser329) Colorimetric Cell-Based ELISA Kit Key=cj_search_index Key=publication_count, value=0 Key=qty_in_warehouses Key=is_recurring, value=No Key=visibility, value=Catalog, Search Key=tax_class_id, value=Taxable Goods Key=featured, value=No Key=featured_image, value=Yes Key=fb_product, value= Key=custom_product_page, value=No Key=free_shipping, value=No Key=template, value=cell-based-phospho-elisa-kits Key=price, value=540.0000 Key=weight, value=1.0000 Key=meta_title, value=FOXO1A (Phospho-Ser329) Colorimetric Cell-Based ELISA Kit Price Key=meta_description, value=FOXO1A (Phospho-Ser329) Colorimetric Cell-Based ELISA Kit EKC2072 Key=image, value=/b/o/boster-box.png Key=small_image, value=/b/o/boster-box.png Key=thumbnail, value=/b/o/boster-box.png Key=url_key, value=foxo1a-phospho-ser329-colorimetric-cell-based-elisa-kit-ekc2072-boster Key=url_path, value=foxo1a-phospho-ser329-colorimetric-cell-based-elisa-kit-ekc2072-boster Key=options_container, value=Product Info Column Key=image_label, value=Boster Kit Box Key=small_image_label, value=Boster Kit Box Key=thumbnail_label, value=Boster Kit Box Key=msrp_display_actual_price_type, value= Key=gift_message_available, value=No Key=size, value=1 kit, containing two 96-well plates and all necessary reagents Key=gene_full_name, value=Forkhead box protein O1 Key=uniprot_id, value=Q12778 Key=assay_range, value=> 5000 cells/well Key=applications, value=ELISA Key=reactivity, value=Human, Mouse, Rat Key=source_company, value=AssayBiotech CBP1159; Cost: 300 Key=molecular_weight, value=69662 MW Key=product_category, value=Cell-Based ELISA Kits Key=rating_value, value=100 Key=review_count, value=24 Key=mp_exclude_sitemap, value=No Key=cj_related_products, value=Alveolar Rhabdomyosarcoma:EKC1926|A01819-1^Decidualization:A01313^Rhabdomyosarcoma, Embryonal:PB9195|A00073|A01809-2 Key=description, value=The FOXO1A (Phospho-Ser329) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FOXO1A (Phospho-Ser329) protein expression profile in cells. The kit can be used for measuring the relative amounts of FOXO1A (Phospho-Ser329) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FOXO1A (Phospho-Ser329). Key=short_description, value=The FOXO1A (Phospho-Ser329) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FOXO1A (Phospho-Ser329) protein expression profile in cells. The kit can be used for measuring the relative amounts of FOXO1A (Phospho-Ser329) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FOXO1A (Phospho-Ser329). Key=gene_name, value=FOXO1 Key=synonyms, value=FKHR;forkhead box O1A (FKHR) Forkhead box protein O1A;Forkhead in rhabdomyosarcoma;FOXO1 Key=sample_type, value=Cell lines Key=kit_components, value=FOXO1A (Phospho-Ser329) Key=subcellular_localization, value=Cytoplasm. Nucleus. Shuttles between the cytoplasm and nucleus. Largely nuclear in unstimulated cells. In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (By similarity). Insulin-induced phosphorylation at Ser-256 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteosomal pathway. Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation. Phosphorylation by NLK results in nuclear export. Translocates to the nucleus upon oxidative stress-induced phosphorylation at Ser-212 by STK4/MST1. SGK1-mediated phosphorylation also results in nuclear translocation. Retained in the nucleus under stress stimuli including oxidative stress, nutrient deprivation or nitric oxide. Retained in the nucleus on methylation. Key=tissue_specificity, value=Ubiquitous. Key=protein_function, value= Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'- TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide- damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner. Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity). Key=storage, value=Store at 4°C for up to 6 months. Key=custom_attribute_1, value=FOXO1A Key=custom_attribute_2, value=Phospho-Ser329 Key=options Key=media_gallery Key=extension_attributes Key=tier_price Key=tier_price_changed Key=category_ids Key=quantity_and_stock_status Key=is_salable Key=website_ids Key=request_path Key=rating_summary Key=_cache_instance_store_filter Key=media_gallery_images
The FOXO1A (Phospho-Ser329) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FOXO1A (Phospho-Ser329) protein expression profile in cells. The kit can be used for measuring the relative amounts of FOXO1A (Phospho-Ser329) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FOXO1A (Phospho-Ser329).
1 kit, containing two 96-well plates and all necessary reagents
Description
The FOXO1A (Phospho-Ser329) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FOXO1A (Phospho-Ser329) protein expression profile in cells. The kit can be used for measuring the relative amounts of FOXO1A (Phospho-Ser329) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FOXO1A (Phospho-Ser329).
Storage & Handling
Store at 4°C for up to 6 months.
Cite This Product
FOXO1A (Phospho-Ser329) Colorimetric Cell-Based ELISA Kit (Boster Biological Technology, Pleasanton CA, USA, Catalog # EKC2072)
Gene/Protein Information For FOXO1 (Source: Uniprot.Org, NCBI)
Gene Name
FOXO1
Full Name
Forkhead box protein O1
Weight
69662 MW
Alternative Names
FKHR;forkhead box O1A (FKHR) Forkhead box protein O1A;Forkhead in rhabdomyosarcoma;FOXO1 FOXO1 FKH1, FKHRA, FOXO1 forkhead box O1 forkhead box protein O1|forkhead box protein O1A|forkhead, Drosophila, homolog of, in rhabdomyosarcoma
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
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In this infographic you will see the following information for FOXO1: database IDs, super-family, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us [email protected].