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Key=sku, value=EKC1223
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Key=created_at, value=2019-02-12 00:20:57
Key=updated_at, value=2024-09-26 01:01:18
Key=mst_search_weight, value=0
Key=status, value=Enabled
Key=name, value=FOXO1A Colorimetric Cell-Based ELISA Kit
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Key=template, value=cell-based-elisa-kits
Key=price, value=480.0000
Key=weight, value=1.0000
Key=meta_title, value=FOXO1A Colorimetric Cell-Based ELISA Kit Price | BosterBio
Key=meta_description, value=FOXO1A Colorimetric Cell-Based ELISA Kit EKC1223
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Key=url_key, value=foxo1a-colorimetric-cell-based-elisa-kit-ekc1223-boster
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Key=image_label, value=Boster Kit Box
Key=small_image_label, value=Boster Kit Box
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Key=size, value=1 kit, containing one 96-well plate and all necessary reagents
Key=gene_full_name, value=Forkhead box protein O1
Key=uniprot_id, value=Q12778
Key=assay_range, value=> 5000 cells/well
Key=applications, value=ELISA
Key=reactivity, value=Human, Mouse, Rat
Key=source_company, value=AssayBiotech CB5275; Cost: 240
Key=molecular_weight, value=69662 MW
Key=product_category, value=Cell-Based ELISA Kits
Key=rating_value, value=99.4
Key=review_count, value=21
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Key=cj_related_products, value=Alveolar Rhabdomyosarcoma:M01819-2^Rhabdomyosarcoma, Embryonal:PB9195|EKC2411|A00073S322S325|A01809-2|M03238
Key=description, value=The FOXO1A Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FOXO1A protein expression profile in cells. The kit can be used for measuring the relative amounts of FOXO1A in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FOXO1A.
Key=short_description, value=The FOXO1A Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FOXO1A protein expression profile in cells. The kit can be used for measuring the relative amounts of FOXO1A in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FOXO1A.
Key=gene_name, value=FOXO1
Key=synonyms, value=FKHR;forkhead box O1A (FKHR) Forkhead box protein O1A;Forkhead in rhabdomyosarcoma;FOXO1
Key=sample_type, value=Cell lines
Key=kit_components, value=FOXO1A
Key=subcellular_localization, value=Cytoplasm. Nucleus. Shuttles between the cytoplasm and nucleus. Largely nuclear in unstimulated cells. In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (By similarity). Insulin-induced phosphorylation at Ser-256 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteosomal pathway. Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation. Phosphorylation by NLK results in nuclear export. Translocates to the nucleus upon oxidative stress-induced phosphorylation at Ser-212 by STK4/MST1. SGK1-mediated phosphorylation also results in nuclear translocation. Retained in the nucleus under stress stimuli including oxidative stress, nutrient deprivation or nitric oxide. Retained in the nucleus on methylation.
Key=tissue_specificity, value=Ubiquitous.
Key=protein_function, value= Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'- TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide- damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner. Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity).
Key=storage, value=Store at 4°C for up to 6 months.
Key=custom_attribute_1, value=FOXO1A
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