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Product Info Summary
| SKU: | A00565 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-TRPV4 Antibody
SKU/Catalog Number
A00565
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TRPV4 Antibody (Catalog # A00565). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
TRPV4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-TRPV4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00565)
Host
Rabbit
Contents
TRPV4 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TRPV4 antibody was raised against an 18 amino acid peptide near the center of human TRPV4. The immunogen is located within amino acids 380 - 430 of TRPV4.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
TRPV4 antibody is human specific. At least six isoforms of TRPV4 are known to exist. This antibody is predicted to not cross-react with other TRP protein family members.
Reactive Species
A00565 is reactive to TRPV4 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
98281 MW
Background of TRPV4
The transient receptor potential (TRP) protein family consists of a diverse group of cation channels functioning in a variety of homeostatic and regulatory pathways. Four subfamilies exist, based on channel domain homology: C type (canonical), V type (vanilloid receptor related), M type (melastatin related) and P type (PKD) (1). TRPV4, belongs to the V type subfamily and plays a role in systemic osmoregulation (2,3). TRPV4 is a calcium channel multi-pass membrane protein activated by various stimuli, including thermal stress, fatty acid metabolites and hypotonicity (3). TRPV4 is highly expressed in lung and kidney and widely expressed in brain. It plays an important role in regulating neural excitability (4).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00565 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TRPV4 antibody can be used for detection of TRPV4 by Western blot at 1 μg/ml. Antibody can also be used for Immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TRPV4 in (A) human testis tissue and (B) SK-N-SH cell lysate with TRPV4 antibody at 1 μg/mL.
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Immunohistochemistry of TRPV4 in human lung tissue with TRPV4 antibody at 5 μg/mL.
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Immunofluorescence of TRPV4 in human lung tissue with TRPV4 antibody at 20 μg/mL.
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Immunofluorescence of TRPV4 in human kidney tissue with TRPV4 antibody at 5 μg/ml.
Red: TRPV4 Antibody (A00565)
Blue: DAPI staining
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Immunohistochemistry of TRPV4 in human kidney tissue with TRPV4 antibody at 2 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For TRPV4 (Source: Uniprot.org, NCBI)
Gene Name
TRPV4
Full Name
Transient receptor potential cation channel subfamily V member 4
Weight
98281 MW
Superfamily
transient receptor (TC 1.A.4) family
Alternative Names
SMAL, VRL2, CMT2C, SPSMA, TRP12, VROAC, HMSN2C, OTRPC4, SSQTL1, Transient receptor potential cation channel subfamily V member 4, Osm-9-like TRP channel 4, TrpV4 TRPV4 BCYM3, CMT2C, HMSN2C, OTRPC4, SMAL, SPSMA, SSQTL1, TRP12, VRL2, VROAC transient receptor potential cation channel subfamily V member 4 transient receptor potential cation channel subfamily V member 4|OSM9-like transient receptor potential channel 4|osm-9-like TRP channel 4|osmosensitive transient receptor potential channel 4|transient receptor potential protein 12|vanilloid receptor-like channel 2|vanilloid receptor-related osmotically activated channel
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TRPV4, check out the TRPV4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TRPV4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TRPV4 Antibody (A00565)
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