Data

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Key=entity_id, value=76673
Key=attribute_set_id, value=4
Key=type_id, value=simple
Key=sku, value=A00223
Key=has_options, value=1
Key=required_options, value=1
Key=created_at, value=2020-03-11 06:18:51
Key=updated_at, value=2024-09-26 01:03:50
Key=mst_search_weight, value=0
Key=status, value=Enabled
Key=name, value=Anti-Transcription activator BRG1 SMARCA4 Antibody
Key=cj_search_index
Key=publication_count, value=0
Key=qty_in_warehouses
Key=is_recurring, value=No
Key=visibility, value=Catalog, Search
Key=tax_class_id, value=Taxable Goods
Key=conjugate
Key=featured, value=No
Key=featured_image, value=Yes
Key=fb_product, value=
Key=custom_product_page, value=No
Key=free_shipping, value=No
Key=template, value=antibodies
Key=host, value=Rabbit
Key=quantity_and_stock_status
Key=googleshopping_exclude, value=No
Key=yoast_keyword_score, value=-1368
Key=yoast_content_score, value=60
Key=price, value=449.0000
Key=weight, value=1.0000
Key=meta_title, value=Transcription activator BRG1 SMARCA4 Antibody
Key=meta_description, value=Boster Bio Anti-Transcription activator BRG1 SMARCA4 Antibody (Catalog # A00223). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat. Supplied as 0.1 mg in Liquid form antibody.
Key=image, value=/1/0/109-401-311-rabbit-a-il-8-1-wb-4x3.jpg
Key=small_image, value=/1/0/109-401-311-rabbit-a-il-8-1-wb-4x3.jpg
Key=thumbnail, value=/1/0/109-401-311-rabbit-a-il-8-1-wb-4x3.jpg
Key=url_key, value=anti-transcription-activator-brg1-smarca4-antibody-a00223-boster
Key=url_path, value=anti-il-8-antibody-a00423-boster
Key=options_container, value=Block after Info Column
Key=image_label, value=Western blot analysis of IL-8 expression in Recombinant Human IL-8 50ng (lane 1). IL-8 at 11KD was detected using rabbit anti-IL-8 Antigen Affinity purified polyclonal antibody (Catalog # A00423) at 1:1000. The blot was developed using chemiluminescence (
Key=small_image_label, value=Western blot analysis of IL-8 expression in Recombinant Human IL-8 50ng (lane 1). IL-8 at 11KD was detected using rabbit anti-IL-8 Antigen Affinity purified polyclonal antibody (Catalog # A00423) at 1:1000. The blot was developed using chemiluminescence (
Key=thumbnail_label, value=Western blot analysis of IL-8 expression in Recombinant Human IL-8 50ng (lane 1). IL-8 at 11KD was detected using rabbit anti-IL-8 Antigen Affinity purified polyclonal antibody (Catalog # A00423) at 1:1000. The blot was developed using chemiluminescence (
Key=msrp_display_actual_price_type, value=Use config
Key=gift_message_available, value=No
Key=size, value=0.1 mg
Key=protein_name, value=SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Key=gene_full_name, value=SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Key=uniprot_id, value=P51532
Key=sensitivity
Key=applications, value=ELISA, IF, IHC-P, WB
Key=reactivity, value=Human, Mouse, Rat
Key=form, value=Liquid
Key=concentration, value=1 mg/mL
Key=cross_reactivity, value=SMARCA4 antibody is human, mouse and rat reactive. Multiple isoforms of SMARCA4 are known to exist.
Key=clone_number
Key=predicted_reactivity, value=Bovine
Key=source_company, value=Prosci 7749; Cost: 249
Key=isotype, value=IgG
Key=molecular_weight, value=184646 MW
Key=sample_size_available, value=25ug for $99, contact us for details
Key=related_product_skus, value=EK0413,PB9621,PROTP10145,PROTP10145-1,PROTP10145-2,PROTP10145-3,PROTP19874,PROTP26894,PROTP41324,PROTP67813
Key=product_category, value=Primary Antibodies
Key=research_category, value=Homeostasis
Key=clonality, value=Polyclonal
Key=swatch_image, value=/e/k/ek0852.png
Key=rating_value, value=100
Key=review_count, value=6
Key=mp_exclude_sitemap, value=No
Key=yoast_facebook_image, value=/m/0/m04858-lalba-primary-antibodies-if-testing-1.jpg
Key=yoast_twitter_image, value=/m/0/m04858-lalba-primary-antibodies-if-testing-1.jpg
Key=cj_related_products, value=Rhabdoid Tumor:A00223-1|M00223-1|EKC2609|M08182|A08182Y219|A08182
Key=description, value=Boster Bio Anti-Transcription activator BRG1 SMARCA4 Antibody (Catalog # A00223). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Key=short_description, value=Boster Bio Anti-Transcription activator BRG1 SMARCA4 Antibody (Catalog # A00223). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Key=meta_keyword, value=Anti-Transcription activator BRG1 SMARCA4 Antibody
Key=contents, value=SMARCA4 Antibody is supplied in PBS containing 0.02% sodium azide.
Key=background, value=The SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 4 (SMARCA4) protein, also known as BRG1, is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila (1). Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes (2). The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin (3). In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44 (4,5).
Key=gene_name, value=SMARCA4
Key=synonyms, value=BRG1, SNF2, SWI2, MRD16, RTPS2, BAF190, SNF2L4, SNF2LB, hSNF2b, BAF190A, BRG1, SNF2B, Transcription activator BRG1, ATP-dependent helicase SMARCA4
Key=application_details, value=SMARCA4 antibody can be used for detection of SMARCA4 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry at 2 μg/mL. For Immunoflorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse and rat samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Key=subcellular_localization, value=Nucleus
Key=tissue_specificity, value=Colocalizes with ZEB1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level).
Key=application_notes
Key=description_before_attributes
Key=competitor_equivalent_skus, value=sc 25342|sc 55462|sc 7165|sc 4600|sc 73321|sc 7922|sc 1269|sc 376750|sc 8427|sc 7302|sc 52870|sc 101499|sc 32817|sc 71367
Key=immunogen, value=SMARCA4 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human SMARCA4. The immunogen is located within amino acids 1420 - 1470 of SMARCA4.
Key=purification, value=SMARCA4 antibody is affinity chromatography purified via peptide column.
Key=storage, value=SMARCA4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Key=custom_attribute_1, value=68 kDa
Key=protein_function, value=Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4- dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST- dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial- mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities (By similarity).
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