Data

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Key=entity_id, value=36603
Key=attribute_set_id, value=4
Key=type_id, value=simple
Key=sku, value=A00223-1
Key=has_options, value=1
Key=required_options, value=1
Key=created_at, value=2017-09-22 10:41:40
Key=updated_at, value=2024-10-25 05:02:01
Key=mst_search_weight, value=0
Key=status, value=Enabled
Key=name, value=Anti-BRG1/SMARCA4 Antibody Picoband®
Key=cj_search_index
Key=publication_count, value=0
Key=qty_in_warehouses
Key=is_recurring, value=No
Key=visibility, value=Catalog, Search
Key=tax_class_id, value=Taxable Goods
Key=featured, value=No
Key=featured_image, value=Yes
Key=fb_product, value=
Key=custom_product_page, value=No
Key=free_shipping, value=No
Key=template, value=antibodies
Key=host, value=Rabbit
Key=googleshopping_exclude, value=No
Key=yoast_keyword_score, value=-1172
Key=yoast_content_score, value=30
Key=badge, value=free-antibody-validation
Key=price, value=370.0000
Key=weight, value=1.0000
Key=meta_title, value=BRG1/SMARCA4 Antibody
Key=meta_description, value=Boster Bio Anti-BRG1/SMARCA4 Antibody Picoband® catalog # A00223-1. Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. Supplied as 100μg/vial in Lyophilized form antibody.
Key=image, value=/A/0/A00223-1-BRG1-primary-antibodies-IHC-testing-2.jpg
Key=small_image, value=/A/0/A00223-1-BRG1-primary-antibodies-IHC-testing-2.jpg
Key=thumbnail, value=/A/0/A00223-1-BRG1-primary-antibodies-IHC-testing-2.jpg
Key=gallery, value=/A00237_1.jpg:/A00237_2.jpg:/A00237_3.jpg
Key=url_key, value=anti-brg1-picoband-trade-antibody-a00223-1-boster
Key=url_path, value=anti-brg1-picoband-trade-antibody-a00223-1-boster
Key=options_container, value=Product Info Column
Key=image_label, value=Figure 2. IHC analysis of BRG1 using anti-BRG1 antibody (A00223-1).
BRG1 was detected in paraffin-embedded section of human intestinal cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution)
Key=small_image_label, value=Figure 2. IHC analysis of BRG1 using anti-BRG1 antibody (A00223-1).
BRG1 was detected in paraffin-embedded section of human intestinal cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution)
Key=thumbnail_label, value=Figure 2. IHC analysis of BRG1 using anti-BRG1 antibody (A00223-1).
BRG1 was detected in paraffin-embedded section of human intestinal cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution)
Key=msrp_display_actual_price_type, value=
Key=gift_message_available, value=No
Key=size, value=100 μg/vial
Key=gene_full_name, value=SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Key=uniprot_id, value=P51532
Key=reconstitution, value=Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Key=sensitivity
Key=applications, value=ELISA, IF, IHC, ICC, WB
Key=reactivity, value=Human, Mouse, Rat
Key=form, value=Lyophilized
Key=concentration, value=Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Key=cross_reactivity, value=No cross-reactivity with other proteins.
Key=recommended_detection_systems, value=Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot, and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (SV0002-1) for IHC(P) and ICC.
Key=predicted_reactivity
Key=source_company, value=Boster A00223-1
Key=isotype, value=Rabbit IgG
Key=related_product_skus, value=B0001-5,AR1156,AR0146
Key=product_category, value=Primary Antibodies
Key=research_category, value=Adaptive Immunity, Cell Type Markers, Hematopoietic Progenitors, Host-Virus Interaction, Immunology, Interspecies Interaction, Lymphoid, Microbiology, Myeloid, Stem Cells, T Cells
Key=clonality, value=Polyclonal
Key=swatch_image, value=/a/0/a00222-2-sri-primary-antibodies-wb-testing-1.jpg
Key=rating_value, value=100
Key=review_count, value=6
Key=phospho_site
Key=mp_exclude_sitemap, value=No
Key=yoast_facebook_image, value=/a/0/a00222-2-sri-primary-antibodies-wb-testing-1.jpg
Key=yoast_twitter_image, value=/a/0/a00222-2-sri-primary-antibodies-wb-testing-1.jpg
Key=cj_related_products, value=Rhabdoid Tumor:A12024|M00223|M00223-1|PROTQ9HBD4|M08182
Key=description, value=Boster Bio Anti-BRG1/SMARCA4 Antibody Picoband® catalog # A00223-1. Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=short_description, value=Boster Bio Anti-BRG1/SMARCA4 Antibody Picoband® catalog # A00223-1. Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=meta_keyword, value=Anti-BRG1/SMARCA4 Antibody Picoband®
Key=contents, value=Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05mg NaN₃.
Key=background, value=Transcription activator BRG1 also known as ATP-dependent helicase SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene. The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
Key=gene_name, value=SMARCA4
Key=synonyms, value=Transcription activator BRG1; TP-dependent helicase SMARCA4; BRG1-associated factor 190A; BAF190A; Mitotic growth and transcription activator; Protein BRG-1; Protein brahma homolog 1; SNF2-beta; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; SMARCA4; BAF190A; BRG1; SNF2B; SNF2L4
Key=application_details, value=Western blot, 0.1-0.5μg/ml
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml
Immunocytochemistry/Immunofluorescence, 2μg/ml
ELISA, 0.1-0.5μg/ml

Key=subcellular_localization, value= Nucleus.
Key=tissue_specificity, value= Colocalizes with ZEB1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level).
Key=immunogen, value=E. coli-derived human BRG1 recombinant protein (Position: Q555-E763).
Key=storage, value=Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Key=custom_attribute_1, value=220 kDa
Key=custom_attribute_2, value=WB: human Hela whole cell, human placenta tissue, human MCF-7 whole cell, human A549 whole cell, human A431 whole cell, human SGC-7901 whole cell, human 22RV1 whole cell, rat small intestine tissue, mouse small intestine tissue
IHC: human intestinal cancer tissue, mouse small intestine tissue, rat small intestine tissue
ICC/IF: U20S cell, U20S cell
FCM: U20S cell
Key=protein_function, value= Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self- renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1.
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