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- Table of Contents
Facts about Transcription activator BRG1.
At the exact same time, there's increased recruiting of CREBBP to the promoter with a CREST- dependent mechanism, which contributes to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression includes the release of HDAC1 and recruiting of CREBBP.
Human | |
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Gene Name: | SMARCA4 |
Uniprot: | P51532 |
Entrez: | 6597 |
Belongs to: |
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SNF2/RAD54 helicase family |
ATP-dependent helicase SMARCA4; BAF190; BAF190A; brahma protein-like 1; Brg1; BRG1-associated factor 190A; BRG1SWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily A member 4; BRM/SWI2-related gene 1; EC 3.6.1; EC 3.6.4.-; FLJ39786; global transcription activator homologous sequence; homeotic gene regulator; hSNF2b; Mitotic growth and transcription activator; nuclear protein GRB1; Protein brahma homolog 1; Protein BRG-1; RTPS2; SMARCA4; SNF2; SNF2B; SNF2-beta; SNF2L4; SNF2LB; SNF2-like 4; subfamily a, member 4; sucrose nonfermenting-like 4; SWI/SNF related, matrix
Mass (kDA):
184.646 kDA
Human | |
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Location: | 19p13.2 |
Sequence: | 19; NC_000019.10 (10960997..11062277) |
Colocalizes with ZEB1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level).
Nucleus. Colocalizes with long non-coding RNA Evf2 in nuclear RNA clouds.
PMID: 8232556 by Khavari P.A., et al. BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription.
PMID: 8208605 by Chiba H., et al. Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.