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Product Info Summary
| SKU: | PA1076 |
|---|---|
| Size: | 100 μg/vial |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC |
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Product info
Product Name
Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody
SKU/Catalog Number
PA1076
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody catalog # PA1076. Tested in ELISA, IHC applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1076)
Host
Rabbit
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP2, identical to the related mouse and rat sequences.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
PA1076 is reactive to TIMP2 in Human, Mouse, Rat
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Observed Molecular Weight
91 kDa
Calculated molecular weight
24399 MW
Background of TIMP-2
TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor. This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
PA1076 is guaranteed for ELISA, IHC Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
ELISA, 0.1-0.5μg/ml, -
Positive Control
IHC: Human Mammary Cancer Tissue
Validation Images & Assay Conditions
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Anti-TIMP2 antibody, PA1076, IHC(P)
IHC(P): Human Mammary Cancer Tissue
Protein Target Info & Infographic
Gene/Protein Information For TIMP2 (Source: Uniprot.org, NCBI)
Gene Name
TIMP2
Full Name
Metalloproteinase inhibitor 2
Weight
24399 MW
Superfamily
protease inhibitor I35 (TIMP) family
Alternative Names
Metalloproteinase inhibitor 2;CSC-21K;Tissue inhibitor of metalloproteinases 2;TIMP-2;TIMP2; TIMP2 CSC-21K, DDC8 TIMP metallopeptidase inhibitor 2 metalloproteinase inhibitor 2|testicular secretory protein Li 57|tissue inhibitor of metalloproteinases 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TIMP2, check out the TIMP2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TIMP2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Metalloproteinase inhibitor 2 TIMP2 Antibody (PA1076)
Hello CJ!
PA1076 has been cited in 16 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Inhibition of pulmonary adenoma in diethylnitrosamine-induced rats by Rhizoma paridis saponins
Long-term intravenous administration of carboxylated single-walled carbon nanotubes induces persistent accumulation in the lungs and pulmonary fibrosis via the nuclear factor-kappa B pathway.
Effect of Novel Gasotransmitter hydrogen sulfide on renal fibrosis and connexins expression in diabetic rats
Effect of norcantharidin on proliferation and invasion of human gallbladder carcinoma GBC-SD cells
Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway
The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-?1 pathway
Inhibition of Zymosan-Induced Inflammatory Factors Expression by ATRA Nanostructured Lipid Carriers
MMP-1/2 and TIMP-1/2 expression levels, and the levels of collagenous and elastic fibers correlate with disease progression in a hamster model of tongue cancer
Wu Ty, Zhang Th, Qu Lm, Feng Jp, Tian Ll, Zhang Bh, Li Dd, Sun Yn, Liu M. Int J Clin Exp Pathol. 2013 Dec 15;7(1):56-63. Ecollection 2014. Mir-19A Is Correlated With Prognosis And Apoptosis Of Laryngeal Squamous Cell Carcinoma By Regulating Timp-2...
Qiu Lb, Zhou Y, Wang Q, Yang Ll, Liu Hq, Xu Sl, Qi Yh, Ding Gr, Guo Gz. Toxicology. 2011 Jul 11;285(1-2):31-8. Doi: 10.1016/J.Tox.2011.03.019. Epub 2011 Apr 8. Synthetic Gelatinases Inhibitor Attenuates Electromagnetic Pulse-Induced Blood-Brain Ba...
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