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Product Info Summary
| SKU: | A00097 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-TAU MAPT Antibody
SKU/Catalog Number
A00097
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TAU MAPT Antibody (Catalog # A00097). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
TAU antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-TAU MAPT Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00097)
Host
Rabbit
Contents
TAU antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TAU antibody was raised against a 19 amino acid peptide near the amino terminus of human TAU. The immunogen is located within amino acids 210 - 260 of TAU.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
TAU antibody is human, mouse and rat reactive. Multiple isoforms of TAU are known to exist; this antibody will only detect the two longest isoforms.
Reactive Species
A00097 is reactive to TAU in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
78928 MW
Background of Tau
The microtubial-associated protein TAU (MAPT), more commonly known as TAU, is is normally a highly soluble protein found predominantly in neurons (1), but accumulations of highly phosphorylated tau protein aggregates are observed in several neurodegenerative diseases including Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and frontotemporal lobar dementia. It was thought that these pathological tau aggregates were the toxic form of tau, but recent studies indicate that soluble and highly phosphorylated tau species are more closely associated with synaptic dysfunction and cell loss (2,3). Mutations in the TAU gene have also been associated with several of these neurodegenerative diseases (4).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00097 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TAU antibody can be used for detection of TAU by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human and rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TAU in SK-N-SH cell lysate with TAU antibody at 1 μg/ml.
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Immunohistochemistry of TAU in mouse brain tissue with TAU antibody at 5 μg/ml.
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Western blot analysis of TAU in (A) human and (B) rat brain tissue lysate with TAU antibody at 1 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TAU (Source: Uniprot.org, NCBI)
Gene Name
TAU
Full Name
Microtubule-associated protein tau
Weight
78928 MW
Alternative Names
Microtubial-associated protein tau, MAPT, MAPTL, DDPAC, FTDP-17L, MSTD, MTBT1, MTBT2, PPND, PPP1R103 MAPT DDPAC, FTDP-17L, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, tau-40, MAPT microtubule associated protein tau microtubule-associated protein tau|G protein beta1/gamma2 subunit-interacting factor 1|PHF-tau|neurofibrillary tangle protein|paired helical filament-tau|protein phosphatase 1, regulatory subunit 103
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TAU, check out the TAU Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TAU: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TAU MAPT Antibody (A00097)
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No publications found for A00097
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