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Product Info Summary
| SKU: | MA1093 |
|---|---|
| Size: | 100 μg/vial |
| Reactive Species: | Bovine, Human |
| Host: | Mouse |
| Application: | IHC, WB |
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Product info
Product Name
Anti-Tau Mapt Antibody (Monoclonal, TAU-2)
SKU/Catalog Number
MA1093
Size
100 μg/vial
Form
Lyophilized
Description
Boster Bio Anti-Tau Mapt Antibody (Monoclonal, TAU-2) catalog # MA1093. Tested in IHC, WB applications. This antibody reacts with Bovine, Human.
Storage & Handling
Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Tau Mapt Antibody (Monoclonal, TAU-2) (Boster Biological Technology, Pleasanton CA, USA, Catalog # MA1093)
Host
Mouse
Contents
Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Clonality
Monoclonal
Clone Number
TAU-2
Isotype
Mouse IgG1
Immunogen
Bovine microtubule-associated proteins (MAPs).
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross-reactivity with other proteins
Reactive Species
MA1093 is reactive to Mapt in Bovine, Human
Reconstitution
Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Observed Molecular Weight
272 kDa
Calculated molecular weight
78564 MW
Background of Tau
The microtubule-associated proteins (MAPs) coassemble with tubulin into microtubules in vitro. Microtubule-associated protein tau appears to be enriched in axons. Tau are composed of 352 to 441 amino acids. The isoforms differ from each other by the presence or absence of 29-amino acid or 58-amino acid inserts located in the N terminus and a 31-amino repeat located in the C terminus. tau is important in establishing and maintaining neuronal morphology and is a major component of the neurofibrillary tangles (NFTs) characteristic of Alzheimer's brain. Microtubule-associated protein tau (MTBT1) is mapped to chromosome 17q21.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
MA1093 is guaranteed for IHC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Immunohistochemistry (Paraffin-embedded Section), 1-2μg/ml, Human, bovine, By Heat
Western blot, 0.5-1μg/ml, Human, bovine
Validation Images & Assay Conditions
There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.
Protein Target Info & Infographic
Gene/Protein Information For Mapt (Source: Uniprot.org, NCBI)
Gene Name
Mapt
Full Name
Microtubule-associated protein tau
Weight
78564 MW
Alternative Names
Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau;Mapt;Mtapt, Tau; MAPT DDPAC, FTDP-17L, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, tau-40, MAPT microtubule associated protein tau microtubule-associated protein tau|G protein beta1/gamma2 subunit-interacting factor 1|PHF-tau|neurofibrillary tangle protein|paired helical filament-tau|protein phosphatase 1, regulatory subunit 103
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on Mapt, check out the Mapt Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for Mapt: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Tau Mapt Antibody (Monoclonal, TAU-2) (MA1093)
Hello CJ!
MA1093 has been cited in 9 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Micro-RNA-137 Inhibits Tau Hyperphosphorylation in Alzheimer's Disease and Targets the CACNA1C Gene in Transgenic Mice and Human Neuroblastoma %u2026
Lychee seed extract protects against neuronal injury and improves cognitive function in rats with type II diabetes mellitus with cognitive impairment
The expression of insulin-like growth factor-1 in senior patients with diabetes and dementia
Panax notoginsenoside Rb1 ameliorates Alzheimer?s disease by upregulating brain-derived neurotrophic factor and downregulating Tau protein expression
Chen C, Gu J, Basurto-Islas G, Jin N, Wu F, Gong CX, Iqbal K, Liu F. Sci Rep. 2017 Oct 18;7(1):13478. doi: 10.1038/s41598-017-13791-5. Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer’s disease
Li X, Li M, Li Y, Quan Q, Wang J. Neural Regen Res. 2012 Dec 25;7(36):2860-6. Doi: 10.3969/J.Issn.1673-5374.2012.36.002. Cellular And Molecular Mechanisms Underlying The Action Of Ginsenoside Rg1 Against Alzheimer'S Disease.
Zhu Yf, Li Xh, Yuan Zp, Li Cy, Tian Rb, Jia W, Xiao Zp. Eur J Pharmacol. 2015 Sep 5;762:239-46. Doi: 10.1016/J.Ejphar.2015.06.002. Epub 2015 Jun 3. Allicin Improves Endoplasmic Reticulum Stress-Related Cognitive Deficits Via Perk/Nrf2 Antioxidativ...
Tan Wf, Cao Xz, Wang Jk, Lv Hw, Wu By, Ma H. Clin Exp Pharmacol Physiol. 2010 Oct;37(10):1010-5. Doi: 10.1111/J.1440-1681.2010.05433.X. Protective Effects Of Lithium Treatment For Spatial Memory Deficits Induced By Tau Hyperphosphorylation In Sple...
Tu Q, Pang L, Chen Y, Zhang Y, Zhang R, Lu B, Wang J. Analyst. 2014 Jan 7;139(1):105-15. Doi: 10.1039/C3An01796F. Epub 2013 Oct 25. Effects Of Surface Charges Of Graphene Oxide On Neuronal Outgrowth And Branching.
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Customer Reviews
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Customer Q&As
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17 Customer Q&As for Anti-Tau Mapt Antibody (Monoclonal, TAU-2)
Question
I am looking for to test anti-Tau antibody (Monoclonal, TAU-2) MA1093 on human parietal lobe for research purposes, then I may be interested in using anti-Tau antibody (Monoclonal, TAU-2) MA1093 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?
Verified Customer
Verified customer
Asked: 2020-05-07
Answer
The products we sell, including anti-Tau antibody (Monoclonal, TAU-2) MA1093, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.
Boster Scientific Support
Answered: 2020-05-07
Question
Do you have a BSA free version of anti-Tau antibody (Monoclonal, TAU-2) MA1093 available?
Verified Customer
Verified customer
Asked: 2020-02-20
Answer
I appreciate your recent telephone inquiry. I can confirm that some lots of this anti-Tau antibody (Monoclonal, TAU-2) MA1093 are BSA free. For now, these lots are available and we can make a BSA free formula for you free of charge. It will take 3 extra days to prepare. If you require this antibody BSA free again in future, please do not hesitate to contact me and I will be pleased to check which lots we have in stock that are BSA free.
Boster Scientific Support
Answered: 2020-02-20
Question
We are currently using anti-Tau antibody (Monoclonal, TAU-2) MA1093 for bovine tissue, and we are well pleased with the WB results. The species of reactivity given in the datasheet says bovine, human. Is it possible that the antibody can work on goat tissues as well?
Verified Customer
Verified customer
Asked: 2020-02-06
Answer
The anti-Tau antibody (Monoclonal, TAU-2) (MA1093) has not been validated for cross reactivity specifically with goat tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in goat you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2020-02-06
Question
Will anti-Tau antibody (Monoclonal, TAU-2) MA1093 work on pig WB with parietal lobe?
Verified Customer
Verified customer
Asked: 2019-12-10
Answer
Our lab technicians have not tested anti-Tau antibody (Monoclonal, TAU-2) MA1093 on pig. You can run a BLAST between pig and the immunogen sequence of anti-Tau antibody (Monoclonal, TAU-2) MA1093 to see if they may cross-react. If the sequence homology is close, then you can perform a pilot test. Keep in mind that since we have not validated pig samples, this use of the antibody is not covered by our guarantee. However we have an innovator award program that if you test this antibody and show it works in pig parietal lobe in WB, you can get your next antibody for free.
Boster Scientific Support
Answered: 2019-12-10
Question
I am interested in using your anti-Tau antibody (Monoclonal, TAU-2) for apoptotic process studies. Has this antibody been tested with western blotting on rat brain tissue? We would like to see some validation images before ordering.
Verified Customer
Verified customer
Asked: 2019-12-10
Answer
We appreciate your inquiry. This MA1093 anti-Tau antibody (Monoclonal, TAU-2) is validated on rat brain tissue, tissue lysate, mouse brain. It is guaranteed to work for IHC, WB in bovine, human. Our Boster guarantee will cover your intended experiment even if the sample type has not been be directly tested.
Boster Scientific Support
Answered: 2019-12-10
Question
My colleagues were content with the WB result of your anti-Tau antibody (Monoclonal, TAU-2). However we have been able to see positive staining in leukemic t-cell cytoplasm using this antibody. Is that expected? Could you tell me where is MAPT supposed to be expressed?
Verified Customer
Verified customer
Asked: 2019-09-27
Answer
From what I have seen in literature, leukemic t-cell does express MAPT. Generally MAPT expresses in cytoplasm, cytosol. Regarding which tissues have MAPT expression, here are a few articles citing expression in various tissues:
Brain, Pubmed ID: 1512244, 2484340, 2495000, 2498079, 3131773, 15489334
Cervix carcinoma, Pubmed ID: 16964243, 18220336, 20068231
Cervix carcinoma, and Erythroleukemia, Pubmed ID: 23186163
Fetal brain, Pubmed ID: 2516729
Fetal brain cortex, Pubmed ID: 16443603
Leukemic T-cell, Pubmed ID: 19690332
Liver, Pubmed ID: 24275569
Boster Scientific Support
Answered: 2019-09-27
Question
Is this MA1093 anti-Tau antibody (Monoclonal, TAU-2) reactive to the isotypes of MAPT?
Verified Customer
Verified customer
Asked: 2019-09-20
Answer
The immunogen of MA1093 anti-Tau antibody (Monoclonal, TAU-2) is Bovine microtubule-associated proteins(MAPs). Could you tell me which isotype you are interested in so I can help see if the immunogen is part of this isotype?
Boster Scientific Support
Answered: 2019-09-20
Question
See below the WB image, lot number and protocol we used for parietal lobe using anti-Tau antibody (Monoclonal, TAU-2) MA1093. Please let me know if you require anything else.
Verified Customer
Verified customer
Asked: 2019-08-20
Answer
Thank you very much for the data. Our lab team are working to resolve this as quickly as possible, and we appreciate your patience and understanding! You have provided everything we needed. Please let me know if there is anything you need in the meantime.
Boster Scientific Support
Answered: 2019-08-20
Question
Will anti-Tau antibody (Monoclonal, TAU-2) MA1093 work for WB with parietal lobe?
Verified Customer
Verified customer
Asked: 2019-07-15
Answer
According to the expression profile of parietal lobe, MAPT is highly expressed in parietal lobe. So, it is likely that anti-Tau antibody (Monoclonal, TAU-2) MA1093 will work for WB with parietal lobe.
Boster Scientific Support
Answered: 2019-07-15
Question
I have a question about product MA1093, anti-Tau antibody (Monoclonal, TAU-2). I was wondering if it would be possible to conjugate this antibody with biotin. I would need it to be without BSA or sodium azide. I am planning on using a buffer exchange of sodium azide with PBS only. Would there be problems for me to conjugate the antibody and store it in -20 degrees in small aliquots?
Verified Customer
Verified customer
Asked: 2019-07-15
Answer
We do not advise storing this antibody with PBS buffer only in -20 degrees. If you want to store it in -20 degrees it is best to add some cryoprotectant like glycerol. If you want carrier free MA1093 anti-Tau antibody (Monoclonal, TAU-2), we can provide it to you in a special formula with trehalose and/or glycerol. These molecules will not interfere with conjugation chemistry and provide a good level of protection for the antibody from degradation. Please be sure to specify this in your purchase order.
Boster Scientific Support
Answered: 2019-07-15
Question
I appreciate helping with my inquiry over the phone. Here are the WB image, lot number and protocol we used for parietal lobe using anti-Tau antibody (Monoclonal, TAU-2) MA1093. Let me know if you need anything else.
Verified Customer
Verified customer
Asked: 2019-07-10
Answer
Thanks for the data. You have provided everything we needed. Our lab team are working to resolve your inquiry as quickly as possible, and we appreciate your patience and understanding! Please let me know if there is anything you need in the meantime.
Boster Scientific Support
Answered: 2019-07-10
Question
We bought anti-Tau antibody (Monoclonal, TAU-2) for IHC on liver a few months ago. I am using bovine, and I plan to use the antibody for WB next. I am looking for examining liver as well as fetal brain cortex in our next experiment. Could you please give me some suggestion on which antibody would work the best for WB?
Verified Customer
Verified customer
Asked: 2019-07-03
Answer
I have checked the website and datasheets of our anti-Tau antibody (Monoclonal, TAU-2) and it appears that MA1093 has been tested on bovine in both IHC and WB. Thus MA1093 should work for your application. Our Boster satisfaction guarantee will cover this product for WB in bovine even if the specific tissue type has not been validated. We do have a comprehensive range of products for WB detection and you can check out our website bosterbio.com to find out more information about them.
Boster Scientific Support
Answered: 2019-07-03
Question
Is a blocking peptide available for product anti-Tau antibody (Monoclonal, TAU-2) (MA1093)?
Verified Customer
Verified customer
Asked: 2019-01-29
Answer
We do provide the blocking peptide for product anti-Tau antibody (Monoclonal, TAU-2) (MA1093). If you would like to place an order for it please contact [email protected] and make a special request.
Boster Scientific Support
Answered: 2019-01-29
Question
I was wanting to use your anti-Tau antibody (Monoclonal, TAU-2) for WB for human parietal lobe on frozen tissues, but I want to know if it has been validated for this particular application. Has this antibody been validated and is this antibody a good choice for human parietal lobe identification?
Verified Customer
Verified customer
Asked: 2019-01-18
Answer
It shows on the product datasheet, MA1093 anti-Tau antibody (Monoclonal, TAU-2) has been validated for IHC, WB on bovine, human tissues. We have an innovator award program that if you test this antibody and show it works in human parietal lobe in IHC-frozen, you can get your next antibody for free.
Boster Scientific Support
Answered: 2019-01-18
Question
I see that the anti-Tau antibody (Monoclonal, TAU-2) MA1093 works with WB, what is the protocol used to produce the result images on the product page?
Verified Customer
Verified customer
Asked: 2018-06-06
Answer
You can find protocols for WB on the "support/technical resources" section of our navigation menu. If you have any further questions, please send an email to [email protected]
Boster Scientific Support
Answered: 2018-06-06
Question
Will MA1093 anti-Tau antibody (Monoclonal, TAU-2) work on parafin embedded sections? If so, which fixation method do you recommend we use (PFA, paraformaldehyde, other)?
K. Carter
Verified customer
Asked: 2016-11-25
Answer
You can see on the product datasheet, MA1093 anti-Tau antibody (Monoclonal, TAU-2) as been tested on WB. It is best to use PFA for fixation because it has better tissue penetration ability. PFA needs to be prepared fresh before use. Long term stored PFA turns into formalin, as the PFA molecules congregate and become formalin.
Boster Scientific Support
Answered: 2016-11-25
Question
We have been able to see staining in bovine leukemic t-cell. Do you have any suggestions? Is anti-Tau antibody (Monoclonal, TAU-2) supposed to stain leukemic t-cell positively?
V. Lewis
Verified customer
Asked: 2014-10-31
Answer
From what I have seen in literature leukemic t-cell does express MAPT. From what I have seen in Uniprot.org, MAPT is expressed in parietal lobe, brain, fetal brain, fetal brain cortex, cervix carcinoma, leukemic t-cell, cervix carcinoma erythroleukemia, liver, among other tissues. Regarding which tissues have MAPT expression, here are a few articles citing expression in various tissues:
Brain, Pubmed ID: 1512244, 2484340, 2495000, 2498079, 3131773, 15489334
Cervix carcinoma, Pubmed ID: 16964243, 18220336, 20068231
Cervix carcinoma, and Erythroleukemia, Pubmed ID: 23186163
Fetal brain, Pubmed ID: 2516729
Fetal brain cortex, Pubmed ID: 16443603
Leukemic T-cell, Pubmed ID: 19690332
Liver, Pubmed ID: 24275569
Boster Scientific Support
Answered: 2014-10-31
