Product Info Summary
SKU: | A01001-1 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | IP, WB, RIP |
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Product info
Product Name
Anti-TAR DNA-binding protein 43 TARDBP Antibody
View all TDP-43/TARDBP Antibodies
SKU/Catalog Number
A01001-1
Size
100ul
Form
Liquid
Description
Boster Bio Anti-TAR DNA-binding protein 43 TARDBP Antibody catalog # A01001-1. Tested in WB,IP,RIP applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-TAR DNA-binding protein 43 TARDBP Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01001-1)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human NUDC around the phosphorylation site of S326.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
A01001-1 is reactive to TARDBP in Human, Mouse, Rat
Applications
A01001-1 is guaranteed for IP, WB, RIP Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
44740 MW
Background of TDP-43/TARDBP
4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Gingras AC, et al. (1998) Genes Dev 12(4): 502-513.
Brugarolas J, et al. (2004) Genes Dev 18(23): 2893-2904.
Kumar V, et al. (2000) EMBO J 19(5): 1087-1097.
Moody CA, et al. (2005) J Virol 79(9): 5499-5506.
Burnett PE, et al. (1998) Proc Natl Acad Sci U S A 95(4): 1432-1437.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:500-1:2000
IP: 1:50-1:100
RIP: 1:20-1:50
Validation Images & Assay Conditions
There are currently no images for this product. We are working on uploading them please check back shortly or contact us to expedite our upload process for this antibody.
Protein Target Info & Infographic
Gene/Protein Information For TARDBP (Source: Uniprot.org, NCBI)
Gene Name
TARDBP
Full Name
TAR DNA-binding protein 43
Weight
44740 MW
Alternative Names
ALS10; ALS10TAR DNA-binding protein-43; TAR DNA binding protein; TARDBP; TDP43; TDP-43; TDP-43TAR DNA-binding protein 43 TARDBP ALS10, TDP-43 TAR DNA binding protein TAR DNA-binding protein 43|TAR DNA-binding protein-43
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TARDBP, check out the TARDBP Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TARDBP: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TAR DNA-binding protein 43 TARDBP Antibody (A01001-1)
Hello CJ!
A01001-1 has been cited in 1 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Zhang Y,Yang C,Yang S,Guo Z.MiRNA-27a decreases ultraviolet B irradiation-induced cell damage. J Cell Biochem. 2020 Feb;121(2):1032-1038.doi: 10.1002/jcb.29337.Epub 2019 Aug 26.PMID: 31452277.
Species: Human
A01001-1 usage in article: APP:WB, SAMPLE:HACAT CELLS, DILUTION:1:1000
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