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Product Info Summary
| SKU: | A00445-4 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, ICC, WB |
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Product info
Product Name
Anti-TANK Antibody
SKU/Catalog Number
A00445-4
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-TANK Antibody (Catalog # A00445-4). Tested in ELISA, WB, ICC applications. This antibody reacts with Human.
Storage & Handling
TANK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-TANK Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00445-4)
Host
Rabbit
Contents
TANK Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
TANK antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human TANK. The immunogen is located within amino acids 60 - 110 of TANK.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
ALSFTD antibody is human, mouse and rat reactive. At least two isoforms are known to exist.
Reactive Species
A00445-4 is reactive to TANK in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
47816 MW
Background of TANK
TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-κB. This activation of NF-κB occurs through an association with the kinases IKKε and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the IκB complex. This suggests that in addition to the possibility that TBK1 and IKKε activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-κB proteins. At least two isoforms of TANK are known to exist.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00445-4 is guaranteed for ELISA, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
TANK antibody can be used for the detection of TANK by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of TANK in Daudi cell lysate with TANK antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunocytochemistry of TANK in Daudi cells with TANK antibody at 2.5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For TANK (Source: Uniprot.org, NCBI)
Gene Name
TANK
Full Name
TRAF family member-associated NF-kappa-B activator
Weight
47816 MW
Alternative Names
ITRAF, TRAF2, I-TRAF, ITRAF, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein TANK I-TRAF, ITRAF, TRAF2 TRAF family member associated NFKB activator TRAF family member-associated NF-kappa-B activator|TRAF-interacting protein
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on TANK, check out the TANK Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for TANK: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-TANK Antibody (A00445-4)
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