Anti-Rtn-3 Monoclonal Antibody

Product Name

Anti-Rtn-3 Monoclonal Antibody

View all RTN3 Antibodies

SKU/Catalog Number

M03760

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Rtn-3 Monoclonal Antibody catalog # M03760. Tested in ELISA, IHC applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Rtn-3 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M03760)

Host

Mouse

Contents

Ascitic fluid containing 0.03% sodium azide.

Clonality

Monoclonal

Clone Number

10A8

Isotype

IgG

Immunogen

Purified recombinant fragment of Rtn-3 expressed in E. Coli.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross reactivity with other proteins.

Reactive Species

M03760 is reactive to RTN3 in Human

Applications

M03760 is guaranteed for ELISA, IHC Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

112611 MW

Background of RTN3

Anti Mesothelin Antibody recognizes Mesothelin that is a glycosyl-phosphatidylinositol–anchored glycoprotein present on the cell surface of various human solid tumors. The mesothelin (MSLN) gene encodes a 71-kDa precursor protein that is processed to a 40-kDa glycosylphosphatidylinositol–anchored protein that composes the mature portion and an NH2 terminal 31-kDa fragment called megakaryocyte-potentiating factor that is released from the cell. Mesothelin is a tumor differentiation antigen present at low levels on a restricted set of normal adult tissues, such as mesothelium, but aberrantly over expressed in mesotheliomas, ovarian, and pancreatic cancers. The biological functions of mesothelin remain elusive. A recent study showed that mesothelin binds to MUC16/CA125, and that this interaction mediates cell adhesion, suggesting that there may be an important role for MUC16/CA125 and mesothelin in the metastatic spread of ovarian cancer.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

IHC 1:200-1:1000
ELISA 1:10000

Validation Images & Assay Conditions

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Immunohistochemistry analysis of paraffin-embedded human lung cancer (left) and breast cancer (right) with DAB staining using Rtn-3 monoclonal antibody.

Gene/Protein Information For RTN3 (Source: Uniprot.org, NCBI)

Alternative Names

ASYIPASY interacting protein; HAP; isoforme III; isoforme VI; Neuroendocrine-specific protein-like 2; Neuroendocrine-specific protein-like II; NSPL2NSP-like protein II; NSPLIIhomolog of ASY protein; NSP-like protein 2; reticulon 3; reticulon-3; RTN3-A1 RTN3 ASYIP, HAP, NSPL2, NSPLII-A1, RTN3 reticulon 3 reticulon-3|ASY interacting protein|NSP-like protein 2|NSP-like protein II|homolog of ASY protein|neuroendocrine-specific protein-like 2|neuroendocrine-specific protein-like II

For more info on RTN3, check out the RTN3 Infographic

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In this infographic, you will see the following information for RTN3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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