Reticulon-3 Antibodies

AND RTN3 ELISA kits, Reticulon-3 Proteins

Many biological assays use antibodies to detect Reticulon-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Reticulon-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Reticulon-3 antibodies...

We validate the specificity of these antibodies to Reticulon-3 by testing them on tissues known to express RTN3 positively and negatively. Browse below to find the RTN3 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RTN3 Infographic by Boster Bio

All RTN3 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Rtn-3 Monoclonal Antibody

Human

ELISA, IHC

$380
Cat # M03760
100ul

RTN3 (NM_006054) Human Over-expression Lysate

Human

$628
Cat # LS010313
100 µg

RTN3 Overview

Facts about Reticulon-3.

RTN3 3D structure. Source: alphafold

Reticulon-3 (RTN3)

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing.

May cause caspase-8 cascade and apoptosis. May prefer BCL2 translocation to the mitochondria upon endoplasmic reticulum stress.

Gene Information

Human
Gene Name:	RTN3
Uniprot:	O95197
Entrez:	10313

Family

Belongs to:

No superfamily

Alternative Names

ASYIPASY interacting protein; HAP; isoforme III; isoforme VI; Neuroendocrine-specific protein-like 2; Neuroendocrine-specific protein-like II; NSPL2NSP-like protein II; NSPLIIhomolog of ASY protein; NSP-like protein 2; reticulon 3; reticulon-3; RTN3-A1

Molecular Weight

Mass (kDA):
112.611 kDA

Genomic Context


Human

Location:	11q13.1
Sequence:	11; NC_000011.10 (63681315..63759891)

Tissue Specificity

Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level). Three times more abundant in macula than in peripheral retina. Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle. Isoform 2 is only found in melanoma.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.

Diseases

Alzheimer's Disease
Nervousness
Neurodegenerative Disorders
Plaque, Amyloid
Tissue Adhesions
Endoplasmic Reticulum Stress
Impaired Cognition
Senile Plaques
Atherosclerosis
Malignant Neoplasms
Neoplasms
Neurofibrillary Tangles

Gliosis
Amyloid Deposition
Rheumatic Heart Disease
Spastic Paraplegia, Hereditary
Parkinson Disease
Paraplegia
Neuroblastoma

Interacting Proteins

CDIPT
PPP2R3C
PTPN9
SNX1
TERF1

Pathways

Regeneration
Transport
Pathogenesis
Secretion
Localization
Cell Death
Rna Interference
Cell Adhesion
Er Overload Response
Axon Regeneration
Protein Secretion
Cerebellum Development
Release Of Cytochrome C From Mitochondria

Reverse Transcription
Sensitization
Cognition
Hormone Secretion
Secretory Pathway
Mitosis
Response To Endoplasmic Reticulum Stress

PTMs

Cleavage

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RTN3

References

PMID: 10331947 by Moreira E.F., et al. Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13.

PMID: 12811824 by Qi B., et al. Pro-apoptotic ASY/Nogo-B protein associates with ASYIP.