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Product Info Summary
| SKU: | M10789 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse |
| Host: | Mouse |
| Application: | Flow Cytometry, WB |
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Product info
Product Name
Anti-RLTPR Purified CARMIL2 Monoclonal Antibody
SKU/Catalog Number
M10789
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-RLTPR Purified CARMIL2 Monoclonal Antibody (Catalog# M10789). Tested in Flow Cytometry, WB application(s). This antibody reacts with Mouse, Human.
Storage & Handling
Store at 2-8°C. Do not freeze.
Cite This Product
Anti-RLTPR Purified CARMIL2 Monoclonal Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # M10789)
Host
Mouse
Contents
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Clonality
Monoclonal
Clone Number
EM-53
Isotype
Mouse IgG1 kappa
Immunogen
Murine RLTPR. The mouse monoclonal antibody EM-53 recognizes RLTPR / CARMIL2, an intracellular protein playing a role in actin filament elongation.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
As in case with other anti-CD170 antibodies, this antibody cross-reacts with Siglec-14, whose first two Ig domains are almost identical to those of CD170.
Reactive Species
M10789 is reactive to CARMIL2 in Human, Mouse
Reconstitution
Observed Molecular Weight
42 kDa
Calculated molecular weight
154689 MW
Background of CARMIL2
RLTPR / CARMIL2 (RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing; capping protein regulator and myosin 1 linker 2), also known as LRRC16C, is a cytosolic protein, which with high affinity binds CAPZA2 (capping protein muscle actin Z-line alpha 2) and decreases CAPZA2 affinity for actin barbed ends. RLTPR / CARMIL2 increases the rate of actin filament elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Its interaction with CAPZA2 is essential for lamellipodial protrusion and cell translocation. RLTPR / CARMIL2 is crutial for T cell costimulation via CD28 and this property seems to be independent on its actin-uncapping function. The lack of functional RLTPR / CARMIL2 molecules impeded the differentiation toward Th1 and Th17 fates of both human and murine CD4+ T cells and leads to combined immunodeficiency. Expression of RLTPR / CARMIL2 was also detected in human and murine B cells, but it seems not to be involved in BCR-mediated signaling.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
M10789 is guaranteed for Flow Cytometry, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Flow cytometry: 1-4 µg/ml. Intracellular staining.
Validation Images & Assay Conditions
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Protein Target Info & Infographic
Gene/Protein Information For CARMIL2 (Source: Uniprot.org, NCBI)
Gene Name
CARMIL2
Full Name
Capping protein, Arp2/3 and myosin-I linker protein 2
Weight
154689 MW
Superfamily
CARMIL family
Alternative Names
CARMIL2, LRRC16C CARMIL2 CARMIL2b, IMD58, LRRC16C, RLTPR capping protein regulator and myosin 1 linker 2 capping protein, Arp2/3 and myosin-I linker protein 2|F-actin-uncapping protein RLTPR|RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing|RGD, leucine-rich repeat, tropomodulin and proline-rich containing protein|leucine rich repeat containing 16C|leucine-rich repeat-containing protein 16C
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CARMIL2, check out the CARMIL2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CARMIL2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-RLTPR Purified CARMIL2 Monoclonal Antibody (M10789)
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