CARMIL2 Antibodies

AND CARMIL2 ELISA kits, CARMIL2 Proteins

Many biological assays use antibodies to detect CARMIL2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CARMIL2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CARMIL2 antibodies...

We validate the specificity of these antibodies to CARMIL2 by testing them on tissues known to express CARMIL2 positively and negatively. Browse below to find the CARMIL2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CARMIL2 Infographic by Boster Bio

All CARMIL2 Products

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Specificity

Applications

Price

Anti-RLTPR Purified CARMIL2 Monoclonal Antibody

Human, Mouse

Flow Cytometry, WB

$330
Cat # M10789
0.1 mg

RLTPR (CARMIL2) (NM_001013838) Human Over-expression Lysate

Human

$960
Cat # LS146206
100 µg

CARMIL2 Overview

Facts about Capping protein, Arp2/3 and myosin-I linker protein 2.

CARMIL2 3D structure. Source: alphafold

Capping protein, Arp2/3 and myosin-I linker protein 2 (CARMIL2)

Cell membrane-cytoskeleton-associated protein which plays a role in the regulation of actin polymerization in the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity in the leading edges of migrating cells, and hence creates uncapped barbed ends and enhances actin polymerization (PubMed:26466680).

Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations (PubMed:19846667, PubMed:26578515, PubMed:26466680). Involved too in cell migration and invadopodia formation during wound healing (PubMed:19846667, PubMed:26578515, PubMed:26466680).

Gene Information

Human
Gene Name:	CARMIL2
Uniprot:	Q6F5E8
Entrez:	146206

Family

Belongs to:

CARMIL family

Alternative Names

Capping protein, Arp2/3 and myosin-I linker protein 2

Molecular Weight

Mass (kDA):
154.689 kDA

Genomic Context


Human

Location:	16q22.1
Sequence:	16; NC_000016.10 (67645004..67657569)

Tissue Specificity

Expressed in all tissues tested, including thymus, spleen, colon, leukocytes, peripheral blood, skin, skin keratinocytes and skin fibroblasts.

Subcellular Localizations

[Isoform 2]: Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, ruffle. Colocalizes to dynamic vimentin filaments both in the central cytoplasm and at leading edges of migrating cells (PubMed:26578515, PubMed:26466680, PubMed:19846667). Colocalizes with F-actin, Arp2/3 complex and cortactin to leading edge lamellipodia, ruffles and macropinosomes of migrating cells (PubMed:26578515).

Diseases

Immunodeficiency 58 (IMD58)

PTMs

Methylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CARMIL2

References

PMID: 15588584 by Matsuzaka Y., et al. Identification, expression analysis and polymorphism of a novel RLTPR gene encoding a RGD motif, tropomodulin domain and proline/leucine- rich regions.

PMID: 19846667 by Liang Y., et al. Distinct roles for CARMIL isoforms in cell migration.

1 Publications of Boster CARMIL2 Antibodies & ELISA Kits

PubMed ID: 10.1177/1535370220931765, Clinical value of IL-13 and ECP in the serum and sputum of eosinophilic AECOPD p...

*More publications can be found for each product on its corresponding product page