Anti-Ras-related protein R-Ras2 RRAS2 Antibody

Product Name

Anti-Ras-related protein R-Ras2 RRAS2 Antibody

View all TC21/R-Ras2 Antibodies

SKU/Catalog Number

A04117

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-Ras-related protein R-Ras2 RRAS2 Antibody (Catalog # A04117). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

RRAS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Cite This Product

Anti-Ras-related protein R-Ras2 RRAS2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04117)

Host

Rabbit

Contents

RRAS2 Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Rabbit polyclonal RRAS2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human RRAS2. The immunogen is located within the last 50 amino acids of RRAS2.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Two isoforms of RRAS2 exists as a result of alternative splicing event.

Reactive Species

A04117 is reactive to RRAS2 in Human, Mouse

Reconstitution

Observed Molecular Weight

68 kDa

Calculated molecular weight

23400 MW

Background of TC21/R-Ras2

Activating mutations and overexpression of classical Ras subfamily members (K-RAS, N-RAS and H-RAS) have been widely investigated as key events in the development of human cancers. The RRAS subfamily of Ras-related proteins includes RRAS1, RRAS2 (TC21) and RRAS3 (M-Ras) show overall amino acid identity with the classical Ras subfamily (H-Ras, K-Ras and N-Ras) of 55–60%. RRAS2 is a small GTPbinding protein of the Ras superfamily of GTPases. It might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins. RRAS2 has high oncogenic potential and overexpression/mutations have been reported in several tumor tissues and cell lines.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A04117 is guaranteed for ELISA, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

RRAS2 antibody can be used for detection of RRAS2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For RRAS2 (Source: Uniprot.org, NCBI)

Alternative Names

TC21, TC21, Ras-related protein R-Ras2, Ras-like protein TC21 RRAS2 NS12, TC21 RAS related 2 ras-related protein R-Ras2|ras-like protein TC21|related RAS viral (r-ras) oncogene homolog 2|teratocarcinoma oncogene

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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