Anti-Ras-related protein R-Ras2 RRAS2 Antibody

Product Name

Anti-Ras-related protein R-Ras2 RRAS2 Antibody

View all TC21/R-Ras2 Antibodies

SKU/Catalog Number

A04117-1

Size

100ul

Form

Liquid

Description

Boster Bio Anti-Ras-related protein R-Ras2 RRAS2 Antibody catalog # A04117-1. Tested in WB applications. This antibody reacts with Human,Mouse,Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Ras-related protein R-Ras2 RRAS2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04117-1)

Host

Rabbit

Contents

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from human MST-3

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A04117-1 is reactive to RRAS2 in Human, Mouse, Rat

Applications

A04117-1 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

Calculated molecular weight

23400 MW

Background of TC21/R-Ras2

Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.

Schinkmann K., J. Biol. Chem. 272:28695-28703(1997).
Zhou T.-H., J. Biol. Chem. 275:2513-2519(2000).
Dunham A., Nature 428:522-528(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1:500-1:2000

Validation Images & Assay Conditions

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Figure 1. Western blotting validation for Anti-Ras-related protein R-Ras2 RRAS2 Antibody A04117-1

Western blot analysis of extracts of various cell lines

Gene/Protein Information For RRAS2 (Source: Uniprot.org, NCBI)

Alternative Names

ras-related protein R-Ras2; related RAS viral (r-ras) oncogene homolog 2; RRAS2; TC21; TC21Ras-like protein TC21; Teratocarcinoma oncogene RRAS2 NS12, TC21 RAS related 2 ras-related protein R-Ras2|ras-like protein TC21|related RAS viral (r-ras) oncogene homolog 2|teratocarcinoma oncogene

For more info on RRAS2, check out the RRAS2 Infographic

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In this infographic, you will see the following information for RRAS2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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