Anti-Proteinase inhibitor 9 (human) SERPINB9 Monoclonal Antibody (PI9-17)

Product Name

Anti-Proteinase inhibitor 9 (human) SERPINB9 Monoclonal Antibody (PI9-17)

View all SERPINB9 Antibodies

SKU/Catalog Number

M04734

Size

125µg

Form

Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.

Description

Boster Bio Anti-Proteinase inhibitor 9 (human) SERPINB9 Monoclonal Antibody (PI9-17) catalog # M04734. Tested in IHC, WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Proteinase inhibitor 9 (human) SERPINB9 Monoclonal Antibody (PI9-17) (Boster Biological Technology, Pleasanton CA, USA, Catalog # M04734)

Host

Mouse

Contents

Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide.

Clonality

Monoclonal

Clone Number

PI9-17

Isotype

Rabbit IgG

Immunogen

Recombinant human full-length PI9 (proteinase inhibitor 9) .

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

Weakly cross-reacts with dog p53.

Reactive Species

M04734 is reactive to SERPINB9 in Human

Reconstitution

Observed Molecular Weight

Calculated molecular weight

44289 MW

Background of SERPINB9

Anti-Glycogen Synthase 1 pS641 antibody is validated by IHC, Western Blot and ELISA. Human muscle glycogen synthase (GS) is responsible for the biosynthesis of glycogen from phosphorylated glucose units. Mammalian liver and muscle contain GS consisting of four subunits with a total molecular weight of 360,000. GS is subject to regulation through both allosteric and covalent modification and occurs in two forms: the phosphorylated inactive form, and the dephosphorylated active form. GS is inactivated by the serine/threonine kinase called glycogen synthase kinase-3 that mainly functions to phosphorylate muscle glycogen synthase. This antibody is specific for the phosphorylated form of GS at S641. Phosphorylation of GS at S641 has been associated with Antiphospholipid Antibody Syndrome.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

M04734 is guaranteed for IHC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (formaldehyde-fixed paraffin-embedded human tissues after pretreatment with 10mM citric acid pH 6.0 for 20min; use ~1:100. For fixed cytospin preparations fix cells for 10min in 10% formalin and then treat them as paraffin sections)
Western Blot (standard procedures)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.

Positive Control

Validation Images & Assay Conditions

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Figure 1: Tissue sections of T-ALCL a) stained with MAb to PI9 (Prod. No. M04734) and b) double-stained with MAb to PI9 (red)

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Figure 2: The following tumors were stained for PI9: a) B-CLL and b) classical Hodgkin disease, nodular sclerosing subtype.

Gene/Protein Information For SERPINB9 (Source: Uniprot.org, NCBI)

Alternative Names

CAP-3; CAP3PI-9; Cytoplasmic antiproteinase 3; Peptidase inhibitor 9; PI9protease inhibitor 9 (ovalbumin type); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9; serpin B9; serpin peptidase inhibitor, clade B (ovalbumin), member 9; serpin peptidase inhibitor, clade B, member 9 SERPINB9 CAP-3, CAP3, PI-9, PI9 serpin family B member 9 serpin B9|cytoplasmic antiproteinase 3|peptidase inhibitor 9|protease inhibitor 9 (ovalbumin type)|serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9|serpin peptidase inhibitor, clade B (ovalbumin), member 9|serpin peptidase inhibitor, clade B, member 9|testicular tissue protein Li 180

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