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Product Info Summary
| SKU: | A00640 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Protein jagged-1 JAG1 Antibody
SKU/Catalog Number
A00640
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Protein jagged-1 JAG1 Antibody (Catalog # A00640). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
JAG1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-Protein jagged-1 JAG1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00640)
Host
Rabbit
Contents
JAG1 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
JAG1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human JAG1. The immunogen is located within the last 50 amino acids of JAG1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
JAG1 antibody is human, mouse and rat reactive. At least two isoforms of JAG1 are known to exist; this antibody will detect both isoforms.
Reactive Species
A00640 is reactive to JAG1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
133799 MW
Background of JAG1
The LIN-12/Notch family of transmembrane receptors plays a central role in development by regulating cell fate decisions (1). Ligands for Notch include JAG1, JAG2 and Delta. JAG1 is one of the DSL (Delta, Serrate, Lag2) transmembrane proteins that can activate Notch. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis (1,2). JAG1 is widely expressed in adult and fetal tissues and the mutation of the JAG1 gene is associated with Familial Tetrology of Fallot (3). JAG1 expression is associated with prostate cancer metastasis and is up-regulated in cervical squamous cell carcinoma (4,5).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00640 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
JAG1 antibody can be used for detection of JAG1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of JAG1 in HeLa cell lysate with JAG1 antibody at 1 μg/ml.
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Immunohistochemistry of JAG1 in human spleen tissue with JAG1 antibody at 5 μg/ml.
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Immunofluorescence of JAG1 in human spleen tissue with JAG1 antibody at 20 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For JAG1 (Source: Uniprot.org, NCBI)
Gene Name
JAG1
Full Name
Protein jagged-1
Weight
133799 MW
Alternative Names
Jagged 1, AGS, AHD, AWS, CD339, HJ1, JAGL1 JAG1 AGS, AGS1, AHD, AWS, CD339, DCHE, HJ1, JAGL1 jagged canonical Notch ligand 1 protein jagged-1
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on JAG1, check out the JAG1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for JAG1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Protein jagged-1 JAG1 Antibody (A00640)
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