Protein jagged-1 Antibodies

AND JAG1 ELISA kits, Protein jagged-1 Proteins

Many biological assays use antibodies to detect Protein jagged-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein jagged-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein jagged-1 antibodies...

We validate the specificity of these antibodies to Protein jagged-1 by testing them on tissues known to express JAG1 positively and negatively. Browse below to find the JAG1 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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JAG1 Infographic by Boster Bio

All JAG1 Products

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Anti-Protein jagged-1 JAG1 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A00640
0.1 mg

Anti-Jagged1 (JAG1) Mouse Monoclonal Antibody [Clone ID: OTI3A10]

Human, Mouse, Rat

IHC, WB

$523
Cat # M00640
100 µl

Anti-Jagged1/JAG1 Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A00640-2
100 μg/vial

Anti-JAG1 Rabbit Monoclonal Antibody

Human

IHC, WB

$370
Cat # M00640-1
100 μl/vial

Jagged1 (JAG1) (NM_000214) Human Over-expression Lysate

Human

$628
Cat # LS000182
100 µg

Human Jagged1 ELISA Kit PicoKine®

Human

ELISA

$499
Cat # EK2224
96 wells/kit, with removable strips.

JAG1 Overview

Facts about Protein jagged-1.

JAG1 3D structure. Source: alphafold

Protein jagged-1 (JAG1)

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510).

Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity).

Gene Information

Human
Gene Name:	JAG1
Uniprot:	P78504
Entrez:	182

Family

Belongs to:

No superfamily

Alternative Names

AGS; AHDMGC104644; Alagille syndrome; AWS; CD339 antigen; CD339; HJ1; JAG1; Jagged 1; Jagged1; JAGL1; protein jagged-1

Molecular Weight

Mass (kDA):
133.799 kDA

Genomic Context


Human

Location:	20p12.2
Sequence:	20; NC_000020.11 (10637684..10673999, complement)

Tissue Specificity

Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Alagille Syndrome
Malignant Neoplasms
Neoplasms
Haploinsufficiency
Malignant Neoplasm Of Breast
Congenital Heart Defects
Tetralogy Of Fallot
Carcinoma
Cholestasis
Stenosis
Liver Diseases
Mammary Neoplasms
Cell Transformation, Neoplastic

Developmental Disabilities
Congenital Abnormality
Pulmonary Stenosis
Heart Diseases
Tumor Angiogenesis
Colorectal Cancer
Tissue Adhesions

Interacting Proteins

CD46
NOTCH1

Pathways

Notch Signaling Pathway
Cell Differentiation
Cell Proliferation
Pathogenesis
Cell Cycle
Angiogenesis
Neurogenesis
Regeneration
Lateral Inhibition
Cell Fate Determination
Ear Development
Cell Fate Specification
Localization

Methylation
Dna Methylation
Liver Development
Bone Development
Cell Adhesion
Inner Ear Development
Cell Death

PTMs

Cleavage
Methylation

Phosphorylation
Glycosylation

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JAG1

References

PMID: 9268641 by Oda T., et al. Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12.

PMID: 9207788 by Li L., et al. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1.