Anti-PP4R2 PPP4R2 Antibody

Product Name

Anti-PP4R2 PPP4R2 Antibody

View all PPP4R2 Antibodies

SKU/Catalog Number

A10882

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-PP4R2 PPP4R2 Antibody (Catalog # A10882). Tested in WB applications. This antibody reacts with Human, Mouse.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-PP4R2 PPP4R2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A10882)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human PP4R2.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A10882 is reactive to PPP4R2 in Human, Mouse

Reconstitution

Calculated molecular weight

46898 MW

Background of PPP4R2

Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.

Hastie C.J., Biochem. J. 347:845-855(2000).
Zhang W., Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
Mural R.J., Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A10882 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Validation Images & Assay Conditions

Gene/Protein Information For PPP4R2 (Source: Uniprot.org, NCBI)

Alternative Names

Serine/threonine-protein phosphatase 4 regulatory subunit 2;PPP4R2;SBBI57; PPP4R2 PP4R2 protein phosphatase 4 regulatory subunit 2 serine/threonine-protein phosphatase 4 regulatory subunit 2

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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